Impact of acoustic pressure on ambient pressure estimation using ultrasound contrast agent

Publication: Research - peer-reviewJournal article – Annual report year: 2010

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Impact of acoustic pressure on ambient pressure estimation using ultrasound contrast agent. / Andersen, Klaus Scheldrup; Jensen, Jørgen Arendt.

In: Ultrasonics, Vol. 50, No. 2, 2010, p. 294-299.

Publication: Research - peer-reviewJournal article – Annual report year: 2010

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Author

Andersen, Klaus Scheldrup; Jensen, Jørgen Arendt / Impact of acoustic pressure on ambient pressure estimation using ultrasound contrast agent.

In: Ultrasonics, Vol. 50, No. 2, 2010, p. 294-299.

Publication: Research - peer-reviewJournal article – Annual report year: 2010

Bibtex

@article{d784a58c99154947a441bccbc8be7455,
title = "Impact of acoustic pressure on ambient pressure estimation using ultrasound contrast agent",
keywords = "Pressure estimation, Contrast agent, Blood pressure",
publisher = "Elsevier BV",
author = "Andersen, {Klaus Scheldrup} and Jensen, {Jørgen Arendt}",
year = "2010",
doi = "10.1016/j.ultras.2009.09.016",
volume = "50",
number = "2",
pages = "294--299",
journal = "Ultrasonics",
issn = "0041-624X",

}

RIS

TY - JOUR

T1 - Impact of acoustic pressure on ambient pressure estimation using ultrasound contrast agent

A1 - Andersen,Klaus Scheldrup

A1 - Jensen,Jørgen Arendt

AU - Andersen,Klaus Scheldrup

AU - Jensen,Jørgen Arendt

PB - Elsevier BV

PY - 2010

Y1 - 2010

N2 - Local blood pressure measurements provide important information on the state of health of organs in the body and can be used to diagnose diseases in the heart, lungs, and kidneys. This paper presents an approach for investigating the ambient pressure sensitivity of a contrast agent using diagnostic ultrasound. The experimental setup resembles a realistic clinical setup utilizing a single array transducer for transmit and receive. The ambient pressure sensitivity of SonoVue (Bracco, Milano, Italy) was measured twice using two different acoustic driving pressures, which were selected based on a preliminary experiment. To compensate for variations in bubble response and to make the estimates more robust, the relation between the energy of the subharmonic and the fundamental component was chosen as a measure over the subharmonic peak amplitude. The preliminary study revealed the growth stage of the subharmonic component to occur at acoustic driving pressures between 300 and 500 kPa. Based on this, the pressure sensitivity was investigated using a driving pressure of 485 and 500 kPa. At 485 kPa, a linear pressure sensitivity of 0.42 dB/kPa was found having a linear correlation coefficient of 0.94. The second measurement series at 485 kPa showed a sensitivity of 0.41 dB/kPa with a correlation coefficient of 0.89. Based on the measurements at 500 kPa, this acoustic driving pressure was concluded to be too high causing the bubbles to be destroyed. The pressure sensitivity for these two measurement series were 0.42 and 0.25 dB/kPa with linear correlation coefficients of 0.98 and 0.93, respectively.

AB - Local blood pressure measurements provide important information on the state of health of organs in the body and can be used to diagnose diseases in the heart, lungs, and kidneys. This paper presents an approach for investigating the ambient pressure sensitivity of a contrast agent using diagnostic ultrasound. The experimental setup resembles a realistic clinical setup utilizing a single array transducer for transmit and receive. The ambient pressure sensitivity of SonoVue (Bracco, Milano, Italy) was measured twice using two different acoustic driving pressures, which were selected based on a preliminary experiment. To compensate for variations in bubble response and to make the estimates more robust, the relation between the energy of the subharmonic and the fundamental component was chosen as a measure over the subharmonic peak amplitude. The preliminary study revealed the growth stage of the subharmonic component to occur at acoustic driving pressures between 300 and 500 kPa. Based on this, the pressure sensitivity was investigated using a driving pressure of 485 and 500 kPa. At 485 kPa, a linear pressure sensitivity of 0.42 dB/kPa was found having a linear correlation coefficient of 0.94. The second measurement series at 485 kPa showed a sensitivity of 0.41 dB/kPa with a correlation coefficient of 0.89. Based on the measurements at 500 kPa, this acoustic driving pressure was concluded to be too high causing the bubbles to be destroyed. The pressure sensitivity for these two measurement series were 0.42 and 0.25 dB/kPa with linear correlation coefficients of 0.98 and 0.93, respectively.

KW - Pressure estimation

KW - Contrast agent

KW - Blood pressure

U2 - 10.1016/j.ultras.2009.09.016

DO - 10.1016/j.ultras.2009.09.016

JO - Ultrasonics

JF - Ultrasonics

SN - 0041-624X

IS - 2

VL - 50

SP - 294

EP - 299

ER -