Immune markers and correlates of protection for vaccine induced immune responses

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Standard

Immune markers and correlates of protection for vaccine induced immune responses. / Thakur, Aneesh; Pedersen, Lasse Eggers; Jungersen, Gregers.

In: Vaccine, Vol. 30, No. 33, 2012, p. 4907– 4920.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Harvard

APA

CBE

MLA

Vancouver

Author

Thakur, Aneesh; Pedersen, Lasse Eggers; Jungersen, Gregers / Immune markers and correlates of protection for vaccine induced immune responses.

In: Vaccine, Vol. 30, No. 33, 2012, p. 4907– 4920.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Bibtex

@article{682f6bb3e6134b36b83a7003faacd754,
title = "Immune markers and correlates of protection for vaccine induced immune responses",
publisher = "Elsevier Ltd.",
author = "Aneesh Thakur and Pedersen, {Lasse Eggers} and Gregers Jungersen",
year = "2012",
doi = "10.1016/j.vaccine.2012.05.049",
volume = "30",
number = "33",
pages = "4907– 4920",
journal = "Vaccine",
issn = "0264-410X",

}

RIS

TY - JOUR

T1 - Immune markers and correlates of protection for vaccine induced immune responses

A1 - Thakur,Aneesh

A1 - Pedersen,Lasse Eggers

A1 - Jungersen,Gregers

AU - Thakur,Aneesh

AU - Pedersen,Lasse Eggers

AU - Jungersen,Gregers

PB - Elsevier Ltd.

PY - 2012

Y1 - 2012

N2 - Vaccines have been a major innovation in the history of mankind and still have the potential to address the challenges posed by chronic intracellular infections including tuberculosis, HIV and malaria which are leading causes of high morbidity and mortality across the world. Markers of an appropriate humoral response currently remain the best validated correlates of protective immunity after vaccination. Despite advancements in the field of immunology over the past few decades currently there are, however, no sufficiently validated immune correlates of vaccine induced protection against chronic infections in neither human nor veterinary medicine. Technological and conceptual advancements within cell-mediated immunology have led to a number of new immunological read-outs with the potential to emerge as correlates of vaccine induced protection. For TH1 type responses, antigen-specific production of interferon-gamma (IFN-γ) has been promoted as a quantitative marker of protective cell-mediated immune responses over the past couple of decades. More recently, however, evidence from several infections has pointed towards the quality of the immune response, measured through increased levels of antigen-specific polyfunctional T cells capable of producing a triad of relevant cytokines, as a better correlate of sustained protective immunity against this type of infections. Also the possibilities to measure antigen-specific cytotoxic T cells (CTL) during infection or in response to vaccination, through recombinant major histocompatibility complex (MHC) class I tetramers loaded with relevant peptides, has opened a new vista to include CTL responses in the evaluation of protective immune responses. Here, we review different immune markers and new candidates for correlates of a protective vaccine induced immune response against chronic infections and how successful they have been in defining the protective immunity in human and veterinary medicine.

AB - Vaccines have been a major innovation in the history of mankind and still have the potential to address the challenges posed by chronic intracellular infections including tuberculosis, HIV and malaria which are leading causes of high morbidity and mortality across the world. Markers of an appropriate humoral response currently remain the best validated correlates of protective immunity after vaccination. Despite advancements in the field of immunology over the past few decades currently there are, however, no sufficiently validated immune correlates of vaccine induced protection against chronic infections in neither human nor veterinary medicine. Technological and conceptual advancements within cell-mediated immunology have led to a number of new immunological read-outs with the potential to emerge as correlates of vaccine induced protection. For TH1 type responses, antigen-specific production of interferon-gamma (IFN-γ) has been promoted as a quantitative marker of protective cell-mediated immune responses over the past couple of decades. More recently, however, evidence from several infections has pointed towards the quality of the immune response, measured through increased levels of antigen-specific polyfunctional T cells capable of producing a triad of relevant cytokines, as a better correlate of sustained protective immunity against this type of infections. Also the possibilities to measure antigen-specific cytotoxic T cells (CTL) during infection or in response to vaccination, through recombinant major histocompatibility complex (MHC) class I tetramers loaded with relevant peptides, has opened a new vista to include CTL responses in the evaluation of protective immune responses. Here, we review different immune markers and new candidates for correlates of a protective vaccine induced immune response against chronic infections and how successful they have been in defining the protective immunity in human and veterinary medicine.

KW - Vaccines

KW - Chronic infections

KW - Correlates of protection

U2 - 10.1016/j.vaccine.2012.05.049

DO - 10.1016/j.vaccine.2012.05.049

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 33

VL - 30

SP - 4907

EP - 4920

ER -