Immune epitope database analysis resource
Publication: Research - peer-review › Journal article – Annual report year: 2012
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Immune epitope database analysis resource. / Kim, Yohan; Ponomarenko, Julia; Zhu, Zhanyang; Tamang, Dorjee; Wang, Peng; Greenbaum, Jason; Lundegaard, Claus; Sette, Alessandro; Lund, Ole; Bourne, Philip E.; Nielsen, Morten; Peters, Bjoern.
In: Nucleic Acids Research, Vol. 40, No. W1, 2012, p. W525-W530.Publication: Research - peer-review › Journal article – Annual report year: 2012
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TY - JOUR
T1 - Immune epitope database analysis resource
A1 - Kim,Yohan
A1 - Ponomarenko,Julia
A1 - Zhu,Zhanyang
A1 - Tamang,Dorjee
A1 - Wang,Peng
A1 - Greenbaum,Jason
A1 - Lundegaard,Claus
A1 - Sette,Alessandro
A1 - Lund,Ole
A1 - Bourne,Philip E.
A1 - Nielsen,Morten
A1 - Peters,Bjoern
AU - Kim,Yohan
AU - Ponomarenko,Julia
AU - Zhu,Zhanyang
AU - Tamang,Dorjee
AU - Wang,Peng
AU - Greenbaum,Jason
AU - Lundegaard,Claus
AU - Sette,Alessandro
AU - Lund,Ole
AU - Bourne,Philip E.
AU - Nielsen,Morten
AU - Peters,Bjoern
PB - Oxford University Press
PY - 2012
Y1 - 2012
N2 - The immune epitope database analysis resource (IEDB-AR: http://tools.iedb.org) is a collection of tools for prediction and analysis of molecular targets of T- and B-cell immune responses (i.e. epitopes). Since its last publication in the NAR webserver issue in 2008, a new generation of peptide:MHC binding and T-cell epitope predictive tools have been added. As validated by different labs and in the first international competition for predicting peptide:MHC-I binding, their predictive performances have improved considerably. In addition, a new B-cell epitope prediction tool was added, and the homology mapping tool was updated to enable mapping of discontinuous epitopes onto 3D structures. Furthermore, to serve a wider range of users, the number of ways in which IEDB-AR can be accessed has been expanded. Specifically, the predictive tools can be programmatically accessed using a web interface and can also be downloaded as software packages.
AB - The immune epitope database analysis resource (IEDB-AR: http://tools.iedb.org) is a collection of tools for prediction and analysis of molecular targets of T- and B-cell immune responses (i.e. epitopes). Since its last publication in the NAR webserver issue in 2008, a new generation of peptide:MHC binding and T-cell epitope predictive tools have been added. As validated by different labs and in the first international competition for predicting peptide:MHC-I binding, their predictive performances have improved considerably. In addition, a new B-cell epitope prediction tool was added, and the homology mapping tool was updated to enable mapping of discontinuous epitopes onto 3D structures. Furthermore, to serve a wider range of users, the number of ways in which IEDB-AR can be accessed has been expanded. Specifically, the predictive tools can be programmatically accessed using a web interface and can also be downloaded as software packages.
KW - immune epitope database analysis resource
KW - immune response
KW - MHC-I
KW - MHC-II
KW - peptide
KW - 00530, General biology - Information, documentation, retrieval and computer applications
KW - 02506, Cytology - Animal
KW - 10064, Biochemistry studies - Proteins, peptides and amino acids
KW - 15002, Blood - Blood and lymph studies
KW - 15004, Blood - Blood cell studies
KW - 34502, Immunology - General and methods
KW - Chemical Coordination and Homeostasis
KW - Computational Biology
KW - B-cell immune system, blood and lymphatics
KW - T-cell immune system, blood and lymphatics
KW - computer software package computer software
KW - epitope prediction tool mathematical and computer techniques
KW - homology mapping tool mathematical and computer techniques
KW - Computer Applications
KW - Immune System
U2 - 10.1093/nar/gks438
DO - 10.1093/nar/gks438
JO - Nucleic Acids Research
JF - Nucleic Acids Research
SN - 0305-1048
IS - W1
VL - 40
SP - W525-W530
ER -