SLEEP phenomena as an early biomarker for Parkinsonism

Research output: Research - peer-reviewArticle in proceedings – Annual report year: 2013

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Idiopathic Rapid-Eye-Movement (REM) sleep Behavior Disorder (iRBD) is one of the most potential biomarkers for Parkinson's Disease (PD) and some atypical PD (AP). It is characterized by REM sleep with abnormal high surface EMG (sEMG) activity. Some twitching during REM sleep is normal, but no one has defined what normal is, and no well-defined methodology for measuring muscle activity in REM sleep exists. The purpose of this study is to investigate the possibility of detecting abnormal high muscle activity during REM sleep in subjects diagnosed with iRBD. This has been achieved by considering the abnormal high muscle activity during REM sleep in iRBD subjects as an outlier detection problem, while exploiting that iRBD muscle activity is more grouped. It was possible to correctly discriminate all iRBD subjects from healthy elderly control subjects and subjects diagnosed with periodic limb movement (PLM) disorder. However, not all PD subjects were classified as having abnormal muscle activity, which is assumed to support the fact that not all PD subjects develop RBD.
Original languageEnglish
Title of host publication2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
PublisherIEEE
Publication date2013
Pages5773 - 5776
ISBN (Print)9781457702167
DOIs
StatePublished - 2013
Event2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Oaska International Convention Center, Osaka, Japan
Duration: 3 Jul 20137 Jul 2013

Conference

Conference2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
LocationOaska International Convention Center
CountryJapan
CityOsaka
Period03/07/201307/07/2013
CitationsWeb of Science® Times Cited: No match on DOI

    Research areas

  • biomechanics, diseases, electromyography, eye, medical disorders, muscle, patient diagnosis, sleep, vision, Engineered Materials, Dielectrics and Plasmas
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