Biocatalytic process development using microfluidic miniaturized systems

Publication: Research - peer-reviewJournal article – Annual report year: 2014

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The increasing interest in biocatalytic processes means there is a clear need for a new systematic development paradigm which encompasses both protein engineering and process engineering. This paper argues that through the use of a new microfluidic platform, data can be collected more rapidly and integrated with process modeling, can provide the basis for validating a reduced number of potential processes. The miniaturized platform should use a smaller reagent inventory and make better use of precious biocatalysts. The EC funded BIOINTENSE project will use ω-transaminase based synthesis of chiral amines as a test-bed for assessing the viability of such a high throughput biocatalytic process development, and in this paper, such a vision for the future is presented.
Original languageEnglish
JournalGreen Processing and Synthesis
Volume3
Issue number1
Pages (from-to)23-31
ISSN2191-9542
DOIs
StatePublished - 2014
CitationsWeb of Science® Times Cited: 7

    Keywords

  • Biocatalysis, Microfluidics, Process development, Transaminase
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