Enterotypes influence temporal changes in gut microbiota

Publication: Research - peer-reviewConference abstract for conference – Annual report year: 2013


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The human gut microbiota plays an important role for human health. The question is whether we can modulate the gut microbiota by changing diet. During a 6-month, randomised, controlled dietary intervention, the effect of consuming a diet following the New Nordic Diet recommendations (NND) as opposed to Average Danish Diet (ADD) on the gut microbiota in humans (n=62) was investigated. Quantitative PCR analysis showed that the microbiota did not change significantly by the intervention. Nevertheless, by stratifying subjects into two enterotypes, distinguished by the Prevotella/Bacteroides ratio (P/B), we were able to detect significant changes in the gut microbiota composition resulting from the interventions. Subjects with a high-P/B experienced more pronounced changes in the gut microbiota composition than subjects with a low-P/B. The study is the first to indicate that enterotypes influence microbiota response to a dietary intervention. The distinguishment of enterotypes by P/B could be a simple approach to assess the effect of diets and other treatments on the gut microbiota.
Original languageEnglish
Publication date2013
Number of pages1
StatePublished - 2013
Event8th Danish Conference on Biotechnology and Molecular Biology - Vejle, Denmark


Conference8th Danish Conference on Biotechnology and Molecular Biology
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