Cerebral 5-HT2A receptor binding is increased in patients with Tourette's syndrome

Research output: Research - peer-reviewJournal article – Annual report year: 2007

  • Author: Haugbøl, Steven

    Copenhagen University Hospital

  • Author: Pinborg, Lars H.

    Copenhagen University Hospital

  • Author: Regeur, Lisbeth

    Copenhagen University Hospital

  • Author: Hansen, Elsebet S.

    Copenhagen University Hospital

  • Author: Bolwig, Tom G.

    Copenhagen University Hospital

  • Author: Nielsen, Finn Årup

    Cognitive Systems, Department of Informatics and Mathematical Modeling, Technical University of Denmark, Richard Petersens Plads, 2800, Kgs. Lyngby, Denmark

  • Author: Svarer, Claus

    Copenhagen University Hospital

  • Author: Skovgaard, Lene T.

    University of Copenhagen

  • Author: Knudsen, Gitte Moos

    Copenhagen University Hospital

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Experimental and clinical data have suggested that abnormalities in the serotonergic neurotransmissions in frontal-subcortical circuits are involved in Tourette's syndrome. To test the hypothesis that the brain's 5-HT2A receptor binding is increased in patients with Tourette's syndrome, PET imaging was performed. Twenty adults with Tourette's syndrome and 20 healthy control subjects were investigated with PET-[18F]altanserin using a bolus-infusion protocol. Regions of interest were delineated automatically on co-registered MRI images, and partial volume-corrected binding parameters were extracted from the PET images. Comparison between control subjects and Tourette's syndrome patients showed increased specific [18F]altanserin binding, not only in the a-priori selected brain regions hypothesized to be involved in Tourette's syndrome, but also post-hoc analysis showed a global up-regulation when testing for a overall difference with a randomization test (p
Original languageEnglish
JournalThe International Journal of Neuropsychopharmacology
Volume10
Issue number2
Pages (from-to)245-252
ISSN1461-1457
DOIs
StatePublished - 2007
CitationsWeb of Science® Times Cited: 35

    Research areas

  • serotonin, Positron emission tomography, brain, human
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