Hyperpolarized singlet NMR on a small animal imaging system

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Standard

Hyperpolarized singlet NMR on a small animal imaging system. / Laustsen, Christoffer ; Pileio, Giuseppe ; Tayler, Michael C. D. ; Brown, Lynda J. ; Brown, Richard C. D. ; Levitt, Malcolm H.; Ardenkjær-Larsen, Jan Henrik.

In: Magnetic Resonance in Medicine, Vol. 68, No. 4, 2012, p. 1262–1265.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Harvard

Laustsen, C, Pileio, G, Tayler, MCD, Brown, LJ, Brown, RCD, Levitt, MH & Ardenkjær-Larsen, JH 2012, 'Hyperpolarized singlet NMR on a small animal imaging system' Magnetic Resonance in Medicine, vol 68, no. 4, pp. 1262–1265., 10.1002/mrm.24430

APA

Laustsen, C., Pileio, G., Tayler, M. C. D., Brown, L. J., Brown, R. C. D., Levitt, M. H., & Ardenkjær-Larsen, J. H. (2012). Hyperpolarized singlet NMR on a small animal imaging system. Magnetic Resonance in Medicine, 68(4), 1262–1265. 10.1002/mrm.24430

CBE

Laustsen C, Pileio G, Tayler MCD, Brown LJ, Brown RCD, Levitt MH, Ardenkjær-Larsen JH. 2012. Hyperpolarized singlet NMR on a small animal imaging system. Magnetic Resonance in Medicine. 68(4):1262–1265. Available from: 10.1002/mrm.24430

MLA

Vancouver

Laustsen C, Pileio G, Tayler MCD, Brown LJ, Brown RCD, Levitt MH et al. Hyperpolarized singlet NMR on a small animal imaging system. Magnetic Resonance in Medicine. 2012;68(4):1262–1265. Available from: 10.1002/mrm.24430

Author

Laustsen, Christoffer ; Pileio, Giuseppe ; Tayler, Michael C. D. ; Brown, Lynda J. ; Brown, Richard C. D. ; Levitt, Malcolm H.; Ardenkjær-Larsen, Jan Henrik / Hyperpolarized singlet NMR on a small animal imaging system.

In: Magnetic Resonance in Medicine, Vol. 68, No. 4, 2012, p. 1262–1265.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Bibtex

@article{a0ea6add3c6b40e3b55ee1664dbbb3f4,
title = "Hyperpolarized singlet NMR on a small animal imaging system",
keywords = "DNP, Hyperpolarization, Single state",
publisher = "John/Wiley & Sons, Inc. John/Wiley & Sons Ltd.",
author = "Christoffer Laustsen and Giuseppe Pileio and Tayler, {Michael C. D.} and Brown, {Lynda J.} and Brown, {Richard C. D.} and Levitt, {Malcolm H.} and Ardenkjær-Larsen, {Jan Henrik}",
year = "2012",
doi = "10.1002/mrm.24430",
volume = "68",
number = "4",
pages = "1262–1265",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",

}

RIS

TY - JOUR

T1 - Hyperpolarized singlet NMR on a small animal imaging system

A1 - Laustsen,Christoffer

A1 - Pileio,Giuseppe

A1 - Tayler,Michael C. D.

A1 - Brown,Lynda J.

A1 - Brown,Richard C. D.

A1 - Levitt,Malcolm H.

A1 - Ardenkjær-Larsen,Jan Henrik

AU - Laustsen,Christoffer

AU - Pileio,Giuseppe

AU - Tayler,Michael C. D.

AU - Brown,Lynda J.

AU - Brown,Richard C. D.

AU - Levitt,Malcolm H.

AU - Ardenkjær-Larsen,Jan Henrik

PB - John/Wiley & Sons, Inc. John/Wiley & Sons Ltd.

PY - 2012

Y1 - 2012

N2 - Nuclear spin hyperpolarization makes a significant advance toward overcoming the sensitivity limitations of in vivo magnetic resonance imaging, particularly in the case of low-gamma nuclei. The sensitivity may be improved further by storing the hyperpolarization in slowly relaxing singlet populations of spin-<br/>1/2 pairs. Here, we report hyperpolarized 13C spin order transferred into and retrieved from singlet spin order using a small animal magnetic resonance imaging scanner. For spins in sites with very similar chemical shifts, singlet spin order is sustained in high magnetic field without requiring strong radiofrequency irradiation. The demonstration of robust singlet-to-magnetization conversion, and vice versa, on a small animal scanner, is promising for future in vivo and clinical deployments.

AB - Nuclear spin hyperpolarization makes a significant advance toward overcoming the sensitivity limitations of in vivo magnetic resonance imaging, particularly in the case of low-gamma nuclei. The sensitivity may be improved further by storing the hyperpolarization in slowly relaxing singlet populations of spin-<br/>1/2 pairs. Here, we report hyperpolarized 13C spin order transferred into and retrieved from singlet spin order using a small animal magnetic resonance imaging scanner. For spins in sites with very similar chemical shifts, singlet spin order is sustained in high magnetic field without requiring strong radiofrequency irradiation. The demonstration of robust singlet-to-magnetization conversion, and vice versa, on a small animal scanner, is promising for future in vivo and clinical deployments.

KW - DNP

KW - Hyperpolarization

KW - Single state

U2 - 10.1002/mrm.24430

DO - 10.1002/mrm.24430

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

IS - 4

VL - 68

SP - 1262

EP - 1265

ER -