Hyperpolarized singlet NMR on a small animal imaging system

Publication: Research - peer-reviewJournal article – Annual report year: 2012

  • Author: Laustsen, Christoffer , Denmark

    Copenhagen University Hospital Hvidovre, Danish Research Centre for Magnetic Resonance, Denmark

  • Author: Pileio, Giuseppe , United Kingdom

    University of Southampton, School of Chemistry, United Kingdom

  • Author: Tayler, Michael C. D. , United Kingdom

    University of Southampton, School of Chemistry, United Kingdom

  • Author: Brown, Lynda J. , United Kingdom

    University of Southampton, School of Chemistry, United Kingdom

  • Author: Brown, Richard C. D. , United Kingdom

    University of Southampton, School of Chemistry, United Kingdom

  • Author: Levitt, Malcolm H., United Kingdom

    University of Southampton, School of Chemistry, United Kingdom

  • Author: Ardenkjær-Larsen, Jan Henrik

    Biomedical Engineering, Department of Electrical Engineering, Technical University of Denmark, Ørsteds Plads, 2800, Kgs. Lyngby, Denmark

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Nuclear spin hyperpolarization makes a significant advance toward overcoming the sensitivity limitations of in vivo magnetic resonance imaging, particularly in the case of low-gamma nuclei. The sensitivity may be improved further by storing the hyperpolarization in slowly relaxing singlet populations of spin-
1/2 pairs. Here, we report hyperpolarized 13C spin order transferred into and retrieved from singlet spin order using a small animal magnetic resonance imaging scanner. For spins in sites with very similar chemical shifts, singlet spin order is sustained in high magnetic field without requiring strong radiofrequency irradiation. The demonstration of robust singlet-to-magnetization conversion, and vice versa, on a small animal scanner, is promising for future in vivo and clinical deployments.
Original languageEnglish
JournalMagnetic Resonance in Medicine
Publication date2012
Volume68
Journal number4
Pages1262–1265
ISSN0740-3194
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 6

Keywords

  • DNP, Hyperpolarization, Single state
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