Hyperpolarized 13C metabolic imaging using dissolution dynamic nuclear polarization

Publication: Research - peer-reviewJournal article – Annual report year: 2012

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Hyperpolarized 13C metabolic imaging using dissolution dynamic nuclear polarization. / Hurd, Ralph E.; Yen, Yi‐Fen; Chen, Albert; Ardenkjær-Larsen, Jan Henrik.

In: Journal of Magnetic Resonance Imaging, Vol. 36, No. 6, 2012, p. 1314-1328.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

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Author

Hurd, Ralph E.; Yen, Yi‐Fen; Chen, Albert; Ardenkjær-Larsen, Jan Henrik / Hyperpolarized 13C metabolic imaging using dissolution dynamic nuclear polarization.

In: Journal of Magnetic Resonance Imaging, Vol. 36, No. 6, 2012, p. 1314-1328.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Bibtex

@article{7862adac36db4ade82b79477d1145894,
title = "Hyperpolarized 13C metabolic imaging using dissolution dynamic nuclear polarization",
publisher = "John/Wiley & Sons, Inc. John/Wiley & Sons Ltd.",
author = "Hurd, {Ralph E.} and Yi‐Fen Yen and Albert Chen and Ardenkjær-Larsen, {Jan Henrik}",
year = "2012",
doi = "10.1002/jmri.23753",
volume = "36",
number = "6",
pages = "1314--1328",
journal = "Journal of Magnetic Resonance Imaging",
issn = "1053-1807",

}

RIS

TY - JOUR

T1 - Hyperpolarized 13C metabolic imaging using dissolution dynamic nuclear polarization

A1 - Hurd,Ralph E.

A1 - Yen,Yi‐Fen

A1 - Chen,Albert

A1 - Ardenkjær-Larsen,Jan Henrik

AU - Hurd,Ralph E.

AU - Yen,Yi‐Fen

AU - Chen,Albert

AU - Ardenkjær-Larsen,Jan Henrik

PB - John/Wiley & Sons, Inc. John/Wiley & Sons Ltd.

PY - 2012

Y1 - 2012

N2 - This article describes the basic physics of dissolution dynamic nuclear polarization (dissolution‐DNP), and the impact of the resulting highly nonequilibrium spin states, on the physics of magnetic resonance imaging (MRI) detection. The hardware requirements for clinical translation of this technology are also presented. For studies that allow the use of externally administered agents, hyperpolarization offers a way to overcome normal magnetic resonance sensitivity limitations, at least for a brief T1‐dependent observation window. A 10,000–100,000‐fold signal‐to‐noise advantage provides an avenue for real‐time measurement of perfusion, metabolite transport, exchange, and metabolism. The principles behind these measurements, as well as the choice of agent, and progress toward the application of hyperpolarized 13C metabolic imaging in oncology, cardiology, and neurology are reviewed. J. Magn. Reson. Imaging 2012; 36:1314–1328. © 2012 Wiley Periodicals, Inc.

AB - This article describes the basic physics of dissolution dynamic nuclear polarization (dissolution‐DNP), and the impact of the resulting highly nonequilibrium spin states, on the physics of magnetic resonance imaging (MRI) detection. The hardware requirements for clinical translation of this technology are also presented. For studies that allow the use of externally administered agents, hyperpolarization offers a way to overcome normal magnetic resonance sensitivity limitations, at least for a brief T1‐dependent observation window. A 10,000–100,000‐fold signal‐to‐noise advantage provides an avenue for real‐time measurement of perfusion, metabolite transport, exchange, and metabolism. The principles behind these measurements, as well as the choice of agent, and progress toward the application of hyperpolarized 13C metabolic imaging in oncology, cardiology, and neurology are reviewed. J. Magn. Reson. Imaging 2012; 36:1314–1328. © 2012 Wiley Periodicals, Inc.

U2 - 10.1002/jmri.23753

DO - 10.1002/jmri.23753

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

SN - 1053-1807

IS - 6

VL - 36

SP - 1314

EP - 1328

ER -