How the signal‐to‐noise ratio influences hyperpolarized 13C dynamic MRS data fitting and parameter estimation

Publication: Research - peer-reviewJournal article – Annual report year: 2012

  • Author: Santarelli, Maria Filomena, Italy

    Institute of Clinical Physiology National Research Council, Italy

  • Author: Positano, Vincenzo, Italy

    Fondazione G. Monasterio CNR Regione Toscana, Italy

  • Author: Giovannetti, Giulio

    Institute of Clinical Physiology National Research Council

  • Author: Frijia, Francesca, Italy

    Fondazione G. Monasterio CNR Regione Toscana, Italy

  • Author: Menichetti, Luca, Italy

    Institute of Clinical Physiology National Research Council, Italy

  • Author: Ardenkjær-Larsen, Jan Henrik

    Biomedical Engineering, Department of Electrical Engineering, Technical University of Denmark, Ørsteds Plads, 2800, Kgs. Lyngby, Denmark

  • Author: De Marchi, Daniele, Italy

    Fondazione G. Monasterio CNR Regione Toscana, Italy

  • Author: Lionetti, Vincenzo, Italy

    Laboratory of Medical Science, Institute of Life Sciences Scuola Superiore Sant'Anna, Italy

  • Author: Aquaro, Giovanni, Italy

    Fondazione G. Monasterio CNR Regione Toscana, Italy

  • Author: Lombardi, Massimo, Italy

    Fondazione G. Monasterio CNR Regione Toscana, Italy

  • Author: Landini, Luigi, Italy

    Department of Information Engineering: EIT University of Pisa, Italy

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MRS of hyperpolarized 13C‐labeled compounds represents a promising technique for in vivo metabolic studies. However, robust quantification and metabolic modeling are still important areas of investigation. In particular, time and spatial resolution constraints may lead to the analysis of MRS signals with low signal‐to‐noise ratio (SNR). The relationship between SNR and the precision of quantitative analysis for the evaluation of the in vivo kinetic behavior of metabolites is unknown. In this article, this topic is addressed by Monte Carlo simulations, covering the problem of MRS signal model parameter estimation, with strong emphasis on the peak amplitude and kinetic model parameters. The results of Monte Carlo simulation were confirmed by in vivo experiments on medium‐sized animals injected with hyperpolarized [1‐13C]pyruvate. The results of this study may be useful for the establishment of experimental planning and for the optimization of kinetic model estimation as a function of the SNR value.
Original languageEnglish
JournalN M R in Biomedicine
Publication date2012
Volume25
Journal number7
Pages925-934
ISSN0952-3480
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 3

Keywords

  • MRS, Hyperpolarized nuclei, Hyperpolarized [1-13C]pyruvate, Signal-to-noise ratio, Kinetic model, Dynamic MRS, In vivo cardiac metabolism
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