Hepatitis C virus-related internal ribosome entry sites are found in multiple genera of the Picornaviridae

Publication: Research - peer-reviewJournal article – Annual report year: 2006

Without internal affiliation

  • Author: Chard, Louisa S.

    BBSRC Institute for Animal Health

  • Author: Bordeleau, Marie-Eve

    McIntyre Medical Sciences Building, Department of Biochemistry

  • Author: Pelletier, J.

    McIntyre Medical Sciences Building, Department of Biochemistry

  • Author: Tanaka, J.

    University of the Ryukyus, Biology and Marine Sciences

  • Author: Belsham, Graham

    Unknown

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The internal ribosome entry site (IRES) elements from porcine enterovirus 8 and simian virus 2, two members of a proposed new genus within the family Picornaviridae, were characterized. These IRES elements, in common with the porcine teschovirus 1 IRES, were found to be related functionally and structurally to the IRES element from Hepatitis C virus, a member of the family Flaviviridae. Partial secondary structure predictions were derived and functional assays demonstrated that these IRES elements continued to be active when eIF4G was cleaved and when the activity of eIF4A was blocked.
Original languageEnglish
JournalJournal of General Virology
Publication date2006
Volume87
IssuePart 4
Pages927-936
ISSN0022-1317
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 27
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