GPX1 Pro198Leu polymorphism, interactions with smoking and alcohol consumption, and risk for lung cancer

Publication: Research - peer-reviewJournal article – Annual report year: 2007

Without internal affiliation

  • Author: Raaschou-Nielsen, Ole

    Danish Cancer Society, Denmark

  • Author: Sørensen, Mette

    Danish Cancer Society, Denmark

  • Author: Hansen, Rikke D.

    Danish Cancer Society, Denmark

  • Author: Frederiksen, Kirsten

    Danish Cancer Society, Denmark

  • Author: Tjønneland, Anne

    Danish Cancer Society, Denmark

  • Author: Overvad, Kim

    Aarhus University Hospital, Denmark

  • Author: Vogel, Ulla Birgitte

    National Institute of Occupational Health

View graph of relations

We genotyped blood samples from 432 lung cancer cases and 798 persons in a comparison group and examined the role of the GPX1 (Pro198Leu, rs1050450) polymorphism and interactions with external exposures in the development of lung cancer. The incidence rate ratio for lung cancer was 0.60 (95% confidence interval: 0.35-1.05) when homozygous carriers of the variant allele were compared with the homozygous carriers of the wild type, and the risk for lung cancer was significantly lower among participants carrying more variant alleles (p-trend = 0.03). We found stronger associations between several smoking variables and alcohol intake and lung cancer risk among GPX1(TT) carriers than among GPX1(CC) and GPX1(CT) carriers. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
Original languageEnglish
JournalCancer Letters
Issue number2
Pages (from-to)293-300
StatePublished - 2007
Externally publishedYes
CitationsWeb of Science® Times Cited: 59
Download as:
Download as PDF
Select render style:
Download as HTML
Select render style:
Download as Word
Select render style:

ID: 3405914