Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism.
Publication: Research - peer-review › Journal article – Annual report year: 2012
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Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism.. / Buescher, Joerg Martin; Liebermeister, Wolfram; Jules, Matthieu; Uhr, Markus; Muntel, Jan; Botella, Eric; Hessling, Bernd; Kleijn, Roelco Jacobus; Le Chat, Ludovic; Lecointe, François; Mäder, Ulrike; Nicolas, Pierre; Piersma, Sjouke; Rügheimer, Frank; Becher, Dörte; Bessieres, Philippe; Bidnenko, Elena; Denham, Emma L; Dervyn, Etienne; Devine, Kevin M; Doherty, Geoff; Drulhe, Samuel; Felicori, Liza; Fogg, Mark J; Goelzer, Anne; Hansen, Annette; Harwood, Colin R; Hecker, Michael; Hubner, Sebastian; Hultschig, Claus; Jarmer, Hanne; Klipp, Edda; Leduc, Aurélie; Lewis, Peter; Molina, Frank; Noirot, Philippe; Peres, Sabine; Pigeonneau, Nathalie; Pohl, Susanne; Rasmussen, Simon; Rinn, Bernd; Schaffer, Marc; Schnidder, Julian; Schwikowski, Benno; Van Dijl, Jan Maarten; Veiga, Patrick; Walsh, Sean; Wilkinson, Anthony J; Stelling, Jörg; Aymerich, Stéphane; Sauer, Uwe.
In: Science, Vol. 335, No. 6072, 2012, p. 1099-1103.Publication: Research - peer-review › Journal article – Annual report year: 2012
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TY - JOUR
T1 - Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism.
A1 - Buescher,Joerg Martin
A1 - Liebermeister,Wolfram
A1 - Jules,Matthieu
A1 - Uhr,Markus
A1 - Muntel,Jan
A1 - Botella,Eric
A1 - Hessling,Bernd
A1 - Kleijn,Roelco Jacobus
A1 - Le Chat,Ludovic
A1 - Lecointe,François
A1 - Mäder,Ulrike
A1 - Nicolas,Pierre
A1 - Piersma,Sjouke
A1 - Rügheimer,Frank
A1 - Becher,Dörte
A1 - Bessieres,Philippe
A1 - Bidnenko,Elena
A1 - Denham,Emma L
A1 - Dervyn,Etienne
A1 - Devine,Kevin M
A1 - Doherty,Geoff
A1 - Drulhe,Samuel
A1 - Felicori,Liza
A1 - Fogg,Mark J
A1 - Goelzer,Anne
A1 - Hansen,Annette
A1 - Harwood,Colin R
A1 - Hecker,Michael
A1 - Hubner,Sebastian
A1 - Hultschig,Claus
A1 - Jarmer,Hanne
A1 - Klipp,Edda
A1 - Leduc,Aurélie
A1 - Lewis,Peter
A1 - Molina,Frank
A1 - Noirot,Philippe
A1 - Peres,Sabine
A1 - Pigeonneau,Nathalie
A1 - Pohl,Susanne
A1 - Rasmussen,Simon
A1 - Rinn,Bernd
A1 - Schaffer,Marc
A1 - Schnidder,Julian
A1 - Schwikowski,Benno
A1 - Van Dijl,Jan Maarten
A1 - Veiga,Patrick
A1 - Walsh,Sean
A1 - Wilkinson,Anthony J
A1 - Stelling,Jörg
A1 - Aymerich,Stéphane
A1 - Sauer,Uwe
AU - Buescher,Joerg Martin
AU - Liebermeister,Wolfram
AU - Jules,Matthieu
AU - Uhr,Markus
AU - Muntel,Jan
AU - Botella,Eric
AU - Hessling,Bernd
AU - Kleijn,Roelco Jacobus
AU - Le Chat,Ludovic
AU - Lecointe,François
AU - Mäder,Ulrike
AU - Nicolas,Pierre
AU - Piersma,Sjouke
AU - Rügheimer,Frank
AU - Becher,Dörte
AU - Bessieres,Philippe
AU - Bidnenko,Elena
AU - Denham,Emma L
AU - Dervyn,Etienne
AU - Devine,Kevin M
AU - Doherty,Geoff
AU - Drulhe,Samuel
AU - Felicori,Liza
AU - Fogg,Mark J
AU - Goelzer,Anne
AU - Hansen,Annette
AU - Harwood,Colin R
AU - Hecker,Michael
AU - Hubner,Sebastian
AU - Hultschig,Claus
AU - Jarmer,Hanne
AU - Klipp,Edda
AU - Leduc,Aurélie
AU - Lewis,Peter
AU - Molina,Frank
AU - Noirot,Philippe
AU - Peres,Sabine
AU - Pigeonneau,Nathalie
AU - Pohl,Susanne
AU - Rasmussen,Simon
AU - Rinn,Bernd
AU - Schaffer,Marc
AU - Schnidder,Julian
AU - Schwikowski,Benno
AU - Van Dijl,Jan Maarten
AU - Veiga,Patrick
AU - Walsh,Sean
AU - Wilkinson,Anthony J
AU - Stelling,Jörg
AU - Aymerich,Stéphane
AU - Sauer,Uwe
PB - American Association for the Advancement of Science
PY - 2012
Y1 - 2012
N2 - Adaptation of cells to environmental changes requires dynamic interactions between metabolic and regulatory networks, but studies typically address only one or a few layers of regulation. For nutritional shifts between two preferred carbon sources of Bacillus subtilis, we combined statistical and model-based data analyses of dynamic transcript, protein, and metabolite abundances and promoter activities. Adaptation to malate was rapid and primarily controlled posttranscriptionally compared with the slow, mainly transcriptionally controlled adaptation to glucose that entailed nearly half of the known transcription regulation network. Interactions across multiple levels of regulation were involved in adaptive changes that could also be achieved by controlling single genes. Our analysis suggests that global trade-offs and evolutionary constraints provide incentives to favor complex control programs.
AB - Adaptation of cells to environmental changes requires dynamic interactions between metabolic and regulatory networks, but studies typically address only one or a few layers of regulation. For nutritional shifts between two preferred carbon sources of Bacillus subtilis, we combined statistical and model-based data analyses of dynamic transcript, protein, and metabolite abundances and promoter activities. Adaptation to malate was rapid and primarily controlled posttranscriptionally compared with the slow, mainly transcriptionally controlled adaptation to glucose that entailed nearly half of the known transcription regulation network. Interactions across multiple levels of regulation were involved in adaptive changes that could also be achieved by controlling single genes. Our analysis suggests that global trade-offs and evolutionary constraints provide incentives to favor complex control programs.
U2 - 10.1126/science.1206871
DO - 10.1126/science.1206871
JO - Science
JF - Science
SN - 0036-8075
IS - 6072
VL - 335
SP - 1099
EP - 1103
ER -