Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Standard

Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism.. / Buescher, Joerg Martin; Liebermeister, Wolfram; Jules, Matthieu; Uhr, Markus; Muntel, Jan; Botella, Eric; Hessling, Bernd; Kleijn, Roelco Jacobus; Le Chat, Ludovic; Lecointe, François; Mäder, Ulrike; Nicolas, Pierre; Piersma, Sjouke; Rügheimer, Frank; Becher, Dörte; Bessieres, Philippe; Bidnenko, Elena; Denham, Emma L; Dervyn, Etienne; Devine, Kevin M; Doherty, Geoff; Drulhe, Samuel; Felicori, Liza; Fogg, Mark J; Goelzer, Anne; Hansen, Annette; Harwood, Colin R; Hecker, Michael; Hubner, Sebastian; Hultschig, Claus; Jarmer, Hanne; Klipp, Edda; Leduc, Aurélie; Lewis, Peter; Molina, Frank; Noirot, Philippe; Peres, Sabine; Pigeonneau, Nathalie; Pohl, Susanne; Rasmussen, Simon; Rinn, Bernd; Schaffer, Marc; Schnidder, Julian; Schwikowski, Benno; Van Dijl, Jan Maarten; Veiga, Patrick; Walsh, Sean; Wilkinson, Anthony J; Stelling, Jörg; Aymerich, Stéphane; Sauer, Uwe.

In: Science, Vol. 335, No. 6072, 2012, p. 1099-1103.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Harvard

Buescher, JM, Liebermeister, W, Jules, M, Uhr, M, Muntel, J, Botella, E, Hessling, B, Kleijn, RJ, Le Chat, L, Lecointe, F, Mäder, U, Nicolas, P, Piersma, S, Rügheimer, F, Becher, D, Bessieres, P, Bidnenko, E, Denham, EL, Dervyn, E, Devine, KM, Doherty, G, Drulhe, S, Felicori, L, Fogg, MJ, Goelzer, A, Hansen, A, Harwood, CR, Hecker, M, Hubner, S, Hultschig, C, Jarmer, H, Klipp, E, Leduc, A, Lewis, P, Molina, F, Noirot, P, Peres, S, Pigeonneau, N, Pohl, S, Rasmussen, S, Rinn, B, Schaffer, M, Schnidder, J, Schwikowski, B, Van Dijl, JM, Veiga, P, Walsh, S, Wilkinson, AJ, Stelling, J, Aymerich, S & Sauer, U 2012, 'Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism.' Science, vol 335, no. 6072, pp. 1099-1103., 10.1126/science.1206871

APA

Buescher, J. M., Liebermeister, W., Jules, M., Uhr, M., Muntel, J., Botella, E., Hessling, B., Kleijn, R. J., Le Chat, L., Lecointe, F., Mäder, U., Nicolas, P., Piersma, S., Rügheimer, F., Becher, D., Bessieres, P., Bidnenko, E., Denham, E. L., Dervyn, E., Devine, K. M., Doherty, G., Drulhe, S., Felicori, L., Fogg, M. J., Goelzer, A., Hansen, A., Harwood, C. R., Hecker, M., Hubner, S., Hultschig, C., Jarmer, H., Klipp, E., Leduc, A., Lewis, P., Molina, F., Noirot, P., Peres, S., Pigeonneau, N., Pohl, S., Rasmussen, S., Rinn, B., Schaffer, M., Schnidder, J., Schwikowski, B., Van Dijl, J. M., Veiga, P., Walsh, S., Wilkinson, A. J., Stelling, J., Aymerich, S., & Sauer, U. (2012). Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism.Science, 335(6072), 1099-1103. 10.1126/science.1206871

CBE

Buescher JM, Liebermeister W, Jules M, Uhr M, Muntel J, Botella E, Hessling B, Kleijn RJ, Le Chat L, Lecointe F, Mäder U, Nicolas P, Piersma S, Rügheimer F, Becher D, Bessieres P, Bidnenko E, Denham EL, Dervyn E, Devine KM, Doherty G, Drulhe S, Felicori L, Fogg MJ, Goelzer A, Hansen A, Harwood CR, Hecker M, Hubner S, Hultschig C, Jarmer H, Klipp E, Leduc A, Lewis P, Molina F, Noirot P, Peres S, Pigeonneau N, Pohl S, Rasmussen S, Rinn B, Schaffer M, Schnidder J, Schwikowski B, Van Dijl JM, Veiga P, Walsh S, Wilkinson AJ, Stelling J, Aymerich S, Sauer U. 2012. Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism. Science. 335(6072):1099-1103. Available from: 10.1126/science.1206871

MLA

Vancouver

Buescher JM, Liebermeister W, Jules M, Uhr M, Muntel J, Botella E et al. Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism. Science. 2012;335(6072):1099-1103. Available from: 10.1126/science.1206871

Author

Buescher, Joerg Martin; Liebermeister, Wolfram; Jules, Matthieu; Uhr, Markus; Muntel, Jan; Botella, Eric; Hessling, Bernd; Kleijn, Roelco Jacobus; Le Chat, Ludovic; Lecointe, François; Mäder, Ulrike; Nicolas, Pierre; Piersma, Sjouke; Rügheimer, Frank; Becher, Dörte; Bessieres, Philippe; Bidnenko, Elena; Denham, Emma L; Dervyn, Etienne; Devine, Kevin M; Doherty, Geoff; Drulhe, Samuel; Felicori, Liza; Fogg, Mark J; Goelzer, Anne; Hansen, Annette; Harwood, Colin R; Hecker, Michael; Hubner, Sebastian; Hultschig, Claus; Jarmer, Hanne; Klipp, Edda; Leduc, Aurélie; Lewis, Peter; Molina, Frank; Noirot, Philippe; Peres, Sabine; Pigeonneau, Nathalie; Pohl, Susanne; Rasmussen, Simon; Rinn, Bernd; Schaffer, Marc; Schnidder, Julian; Schwikowski, Benno; Van Dijl, Jan Maarten; Veiga, Patrick; Walsh, Sean; Wilkinson, Anthony J; Stelling, Jörg; Aymerich, Stéphane; Sauer, Uwe / Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism..

In: Science, Vol. 335, No. 6072, 2012, p. 1099-1103.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Bibtex

@article{96d1b8fe54fc4fc5b3f945abc3279b2f,
title = "Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism.",
publisher = "American Association for the Advancement of Science",
author = "Buescher, {Joerg Martin} and Wolfram Liebermeister and Matthieu Jules and Markus Uhr and Jan Muntel and Eric Botella and Bernd Hessling and Kleijn, {Roelco Jacobus} and {Le Chat}, Ludovic and François Lecointe and Ulrike Mäder and Pierre Nicolas and Sjouke Piersma and Frank Rügheimer and Dörte Becher and Philippe Bessieres and Elena Bidnenko and Denham, {Emma L} and Etienne Dervyn and Devine, {Kevin M} and Geoff Doherty and Samuel Drulhe and Liza Felicori and Fogg, {Mark J} and Anne Goelzer and Annette Hansen and Harwood, {Colin R} and Michael Hecker and Sebastian Hubner and Claus Hultschig and Hanne Jarmer and Edda Klipp and Aurélie Leduc and Peter Lewis and Frank Molina and Philippe Noirot and Sabine Peres and Nathalie Pigeonneau and Susanne Pohl and Simon Rasmussen and Bernd Rinn and Marc Schaffer and Julian Schnidder and Benno Schwikowski and {Van Dijl}, {Jan Maarten} and Patrick Veiga and Sean Walsh and Wilkinson, {Anthony J} and Jörg Stelling and Stéphane Aymerich and Uwe Sauer",
year = "2012",
doi = "10.1126/science.1206871",
volume = "335",
number = "6072",
pages = "1099--1103",
journal = "Science",
issn = "0036-8075",

}

RIS

TY - JOUR

T1 - Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism.

A1 - Buescher,Joerg Martin

A1 - Liebermeister,Wolfram

A1 - Jules,Matthieu

A1 - Uhr,Markus

A1 - Muntel,Jan

A1 - Botella,Eric

A1 - Hessling,Bernd

A1 - Kleijn,Roelco Jacobus

A1 - Le Chat,Ludovic

A1 - Lecointe,François

A1 - Mäder,Ulrike

A1 - Nicolas,Pierre

A1 - Piersma,Sjouke

A1 - Rügheimer,Frank

A1 - Becher,Dörte

A1 - Bessieres,Philippe

A1 - Bidnenko,Elena

A1 - Denham,Emma L

A1 - Dervyn,Etienne

A1 - Devine,Kevin M

A1 - Doherty,Geoff

A1 - Drulhe,Samuel

A1 - Felicori,Liza

A1 - Fogg,Mark J

A1 - Goelzer,Anne

A1 - Hansen,Annette

A1 - Harwood,Colin R

A1 - Hecker,Michael

A1 - Hubner,Sebastian

A1 - Hultschig,Claus

A1 - Jarmer,Hanne

A1 - Klipp,Edda

A1 - Leduc,Aurélie

A1 - Lewis,Peter

A1 - Molina,Frank

A1 - Noirot,Philippe

A1 - Peres,Sabine

A1 - Pigeonneau,Nathalie

A1 - Pohl,Susanne

A1 - Rasmussen,Simon

A1 - Rinn,Bernd

A1 - Schaffer,Marc

A1 - Schnidder,Julian

A1 - Schwikowski,Benno

A1 - Van Dijl,Jan Maarten

A1 - Veiga,Patrick

A1 - Walsh,Sean

A1 - Wilkinson,Anthony J

A1 - Stelling,Jörg

A1 - Aymerich,Stéphane

A1 - Sauer,Uwe

AU - Buescher,Joerg Martin

AU - Liebermeister,Wolfram

AU - Jules,Matthieu

AU - Uhr,Markus

AU - Muntel,Jan

AU - Botella,Eric

AU - Hessling,Bernd

AU - Kleijn,Roelco Jacobus

AU - Le Chat,Ludovic

AU - Lecointe,François

AU - Mäder,Ulrike

AU - Nicolas,Pierre

AU - Piersma,Sjouke

AU - Rügheimer,Frank

AU - Becher,Dörte

AU - Bessieres,Philippe

AU - Bidnenko,Elena

AU - Denham,Emma L

AU - Dervyn,Etienne

AU - Devine,Kevin M

AU - Doherty,Geoff

AU - Drulhe,Samuel

AU - Felicori,Liza

AU - Fogg,Mark J

AU - Goelzer,Anne

AU - Hansen,Annette

AU - Harwood,Colin R

AU - Hecker,Michael

AU - Hubner,Sebastian

AU - Hultschig,Claus

AU - Jarmer,Hanne

AU - Klipp,Edda

AU - Leduc,Aurélie

AU - Lewis,Peter

AU - Molina,Frank

AU - Noirot,Philippe

AU - Peres,Sabine

AU - Pigeonneau,Nathalie

AU - Pohl,Susanne

AU - Rasmussen,Simon

AU - Rinn,Bernd

AU - Schaffer,Marc

AU - Schnidder,Julian

AU - Schwikowski,Benno

AU - Van Dijl,Jan Maarten

AU - Veiga,Patrick

AU - Walsh,Sean

AU - Wilkinson,Anthony J

AU - Stelling,Jörg

AU - Aymerich,Stéphane

AU - Sauer,Uwe

PB - American Association for the Advancement of Science

PY - 2012

Y1 - 2012

N2 - Adaptation of cells to environmental changes requires dynamic interactions between metabolic and regulatory networks, but studies typically address only one or a few layers of regulation. For nutritional shifts between two preferred carbon sources of Bacillus subtilis, we combined statistical and model-based data analyses of dynamic transcript, protein, and metabolite abundances and promoter activities. Adaptation to malate was rapid and primarily controlled posttranscriptionally compared with the slow, mainly transcriptionally controlled adaptation to glucose that entailed nearly half of the known transcription regulation network. Interactions across multiple levels of regulation were involved in adaptive changes that could also be achieved by controlling single genes. Our analysis suggests that global trade-offs and evolutionary constraints provide incentives to favor complex control programs.

AB - Adaptation of cells to environmental changes requires dynamic interactions between metabolic and regulatory networks, but studies typically address only one or a few layers of regulation. For nutritional shifts between two preferred carbon sources of Bacillus subtilis, we combined statistical and model-based data analyses of dynamic transcript, protein, and metabolite abundances and promoter activities. Adaptation to malate was rapid and primarily controlled posttranscriptionally compared with the slow, mainly transcriptionally controlled adaptation to glucose that entailed nearly half of the known transcription regulation network. Interactions across multiple levels of regulation were involved in adaptive changes that could also be achieved by controlling single genes. Our analysis suggests that global trade-offs and evolutionary constraints provide incentives to favor complex control programs.

U2 - 10.1126/science.1206871

DO - 10.1126/science.1206871

JO - Science

JF - Science

SN - 0036-8075

IS - 6072

VL - 335

SP - 1099

EP - 1103

ER -