Genome-Wide Association Study in Dachshund: Identification of a Major Locus Affecting Intervertebral Disc Calcification

Publication: Research - peer-reviewJournal article – Annual report year: 2011

  • Author: Mogensen, Mette Sloth

    University of Copenhagen

  • Author: Karlskov-Mortensen, Peter

    University of Copenhagen

  • Author: Proschowsky, Helle Friis

    Univ Copenhagen, Fac Life Sci, Dept Basic Anim & Vet Sci, DK-1870 Frederiksberg C, Denmark

  • Author: Lingaas, Frode

    Norwegian School of Veterinary Science

  • Author: Lappalainen, Anu

    University of Helsinki

  • Author: Lohi, Hannes

    University of Helsinki

  • Author: Jensen, Vibeke Frøkjær

    Division of Microbiology and Risk Assessment, National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, 2860, Søborg, Denmark

  • Author: Fredholm, Merete

    University of Copenhagen

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Intervertebral disc calcification and herniation commonly affects Dachshund where the predisposition is caused by an early onset degenerative process resulting in disc calcification. A continuous spectrum of disc degeneration is seen within and among clog breeds, suggesting a multifactorial etiology. The number of calcified discs at 2 years of age determined by a radiographic evaluation is a good indicator of the severity of disc degeneration and thus serves as a measure for the risk of developing intervertebral disc herniation. The aim of the study was to identify genetic variants associated with intervertebral disc calcification in Dachshund through a genome-wide association (GWA) study. Based on thorough radiographic examinations, 48 cases with >= 6 disc calcifications or surgically treated for disc herniation and 46 controls with 0-1 disc calcifications were identified. GWA using the Illumina CanineHD BeadChip identified a locus on chromosome 12 from 36.8 to 38.6 Mb with 36 markers reaching genome-wide significance (P-genome = 0.00001-0.026). This study suggests that a major locus on chromosome 12 harbors genetic variations affecting the development of intervertebral disc calcification in Dachshund.
Original languageEnglish
JournalJournal of Heredity
Publication date2011
CitationsWeb of Science® Times Cited: No match on DOI
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ID: 5782020