Genome update: the 1000th genome - a cautionary tale

Publication: Research - peer-reviewJournal article – Annual report year: 2010

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Genome update: the 1000th genome - a cautionary tale. / Lagesen, Karin; Ussery, David; Wassenaar, Gertrude Maria.

In: Microbiology, Vol. 156, 2010, p. 603-608.

Publication: Research - peer-reviewJournal article – Annual report year: 2010

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Lagesen, Karin; Ussery, David; Wassenaar, Gertrude Maria / Genome update: the 1000th genome - a cautionary tale.

In: Microbiology, Vol. 156, 2010, p. 603-608.

Publication: Research - peer-reviewJournal article – Annual report year: 2010

Bibtex

@article{1dd106c119664bd98738db9a198f9e31,
title = "Genome update: the 1000th genome - a cautionary tale",
publisher = "Society for General Microbiology",
author = "Karin Lagesen and David Ussery and Wassenaar, {Gertrude Maria}",
year = "2010",
doi = "10.1099/mic.0.038257-0",
volume = "156",
pages = "603--608",
journal = "Microbiology",
issn = "1350-0872",

}

RIS

TY - JOUR

T1 - Genome update: the 1000th genome - a cautionary tale

A1 - Lagesen,Karin

A1 - Ussery,David

A1 - Wassenaar,Gertrude Maria

AU - Lagesen,Karin

AU - Ussery,David

AU - Wassenaar,Gertrude Maria

PB - Society for General Microbiology

PY - 2010

Y1 - 2010

N2 - There are now more than 1000 sequenced prokaryotic genomes deposited in public databases and available for analysis. Currently, although the sequence databases GenBank, DNA Database of Japan and EMBL are synchronized continually, there are slight differences in content at the genomes level for a variety of logistical reasons, including differences in format and loading errors, such as those caused by file transfer protocol interruptions. This means that the 1000th genome will be different in the various databases. Some of the data on the highly accessed web pages are inaccurate, leading to false conclusions for example about the largest bacterial genome sequenced. Biological diversity is far greater than many have thought. For example, analysis of multiple Escherichia coli genomes has led to an estimate of around 45 000 gene families more genes than are recognized in the human genome. Moreover, of the 1000 genomes available, not a single protein is conserved across all genomes. Excluding the members of the Archaea, only a total of four genes are conserved in all bacteria: two protein genes and two RNA genes.

AB - There are now more than 1000 sequenced prokaryotic genomes deposited in public databases and available for analysis. Currently, although the sequence databases GenBank, DNA Database of Japan and EMBL are synchronized continually, there are slight differences in content at the genomes level for a variety of logistical reasons, including differences in format and loading errors, such as those caused by file transfer protocol interruptions. This means that the 1000th genome will be different in the various databases. Some of the data on the highly accessed web pages are inaccurate, leading to false conclusions for example about the largest bacterial genome sequenced. Biological diversity is far greater than many have thought. For example, analysis of multiple Escherichia coli genomes has led to an estimate of around 45 000 gene families more genes than are recognized in the human genome. Moreover, of the 1000 genomes available, not a single protein is conserved across all genomes. Excluding the members of the Archaea, only a total of four genes are conserved in all bacteria: two protein genes and two RNA genes.

U2 - 10.1099/mic.0.038257-0

DO - 10.1099/mic.0.038257-0

JO - Microbiology

JF - Microbiology

SN - 1350-0872

VL - 156

SP - 603

EP - 608

ER -