Generating highly polarized nuclear spins in solution using dynamic nuclear polarization

Publication: Research - peer-reviewConference article – Annual report year: 2004

  • Author: Wolber, J.

    Amersham Health R&D AB, Medeon, P.A. Hanssonsväg 41, SE-205 , Malmö 12, Sweden

  • Author: Ellner, F.

    Amersham Health R&D AB, Medeon, P.A. Hanssonsväg 41, SE-205 , Malmö 12, Sweden

  • Author: Fridlund, B.

    Amersham Health R&D AB, Medeon, P.A. Hanssonsväg 41, SE-205 , Malmö 12, Sweden

  • Author: Gram, A.

    Amersham Health R&D AB, Medeon, P.A. Hanssonsväg 41, SE-205 , Malmö 12, Sweden

  • Author: Jóhannesson, H.

    Amersham Health R&D AB, Medeon, P.A. Hanssonsväg 41, SE-205 , Malmö 12, Sweden

  • Author: Hansson, G.

    Amersham Health R&D AB, Medeon, P.A. Hanssonsväg 41, SE-205 , Malmö 12, Sweden

  • Author: Hansson, L.H.

    Risø National Laboratory for Sustainable Energy, Technical University of Denmark, Denmark

  • Author: Lerche, M.H.

    Amersham Health R&D AB, Medeon, P.A. Hanssonsväg 41, SE-205 , Malmö 12, Sweden

  • Author: Månsson, S.

    Department of Experimental Research, Malmö University Hospital, SE-205 , Malmö 02, Sweden

  • Author: Servin, R.

    Amersham Health R&D AB, Medeon, P.A. Hanssonsväg 41, SE-205 , Malmö 12, Sweden

  • Author: Thaning, Morten S., Denmark

    Afdeling for Filosofi, Denmark

  • Author: Golman, K.

    Amersham Health R&D AB, Medeon, P.A. Hanssonsväg 41, SE-205 , Malmö 12, Sweden

  • Author: Ardenkjær-Larsen, Jan Henrik

  • Author: St. Goertz, W. Meyer and G. Reicherz

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A method to generate strongly polarized nuclear spins in solution has been developed, using Dynamic Nuclear Polarization (DNP) at a temperature of 1.2K, and at a field of 3.354T, corresponding to an electron spin resonance frequency of 94GHz. Trityl radicals are used to directly polarize 13C and other low-γ nuclei. Subsequent to the DNP process, the solid sample is dissolved rapidly with a warm solvent to create a solution of molecules with highly polarized nuclear spins. Two main applications are proposed: high-resolution liquid state NMR with enhanced sensitivity, and the use of the hyperpolarized solution as an MR imaging agent.
Original languageEnglish
JournalNuclear Instruments & Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment
Publication date2004
Volume526
Journal number1-2
Pages173-181
ISSN0168-9002
DOIs
StatePublished

Conference

Conference9th International Workshop on Polarized Solid Targets and Techniques
Number9
CountryGermany
CityBad Honnef
Period27/10/0329/10/03
CitationsWeb of Science® Times Cited: 69
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