Generating highly polarized nuclear spins in solution using dynamic nuclear polarization

Publication: Research - peer-reviewConference article – Annual report year: 2004

  • Author: Wolber, J.

    Amersham Health R&D AB

  • Author: Ellner, F.

    Amersham Health R&D AB

  • Author: Fridlund, B.

    Amersham Health R&D AB

  • Author: Gram, A.

    Amersham Health R&D AB

  • Author: Jóhannesson, H.

    Amersham Health R&D AB

  • Author: Hansson, G.

    Amersham Health R&D AB

  • Author: Hansson, L.H.

    Risø National Laboratory for Sustainable Energy, Technical University of Denmark, Denmark

  • Author: Lerche, M.H.

    Amersham Health R&D AB

  • Author: Månsson, S.

    Department of Experimental Research, Malmö University Hospital, SE-205 , Malmö 02, Sweden

  • Author: Servin, R.

    Amersham Health R&D AB

  • Author: Thaning, Morten S.

    Afdeling for Filosofi, Denmark

  • Author: Golman, K.

    Amersham Health R&D AB

  • Author: Ardenkjær-Larsen, Jan Henrik

  • Author: St. Goertz, W. Meyer and G. Reicherz

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A method to generate strongly polarized nuclear spins in solution has been developed, using Dynamic Nuclear Polarization (DNP) at a temperature of 1.2K, and at a field of 3.354T, corresponding to an electron spin resonance frequency of 94GHz. Trityl radicals are used to directly polarize 13C and other low-γ nuclei. Subsequent to the DNP process, the solid sample is dissolved rapidly with a warm solvent to create a solution of molecules with highly polarized nuclear spins. Two main applications are proposed: high-resolution liquid state NMR with enhanced sensitivity, and the use of the hyperpolarized solution as an MR imaging agent.

Conference

Conference9th International Workshop on Polarized Solid Targets and Techniques
Number9
CountryGermany
CityBad Honnef
Period27/10/0329/10/03
CitationsWeb of Science® Times Cited: 72
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