• Author: Vogel, Ulla Birgitte

    Unknown

  • Author: Sørensen, M.

  • Author: Hansen, R. D.

  • Author: Tjønneland, A.

  • Author: Overvad, K.

  • Author: Wallin, H.

  • Author: Nexø, B. A.

  • Author: Raaschou-Nielsen, O.

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Homozygous carriers of a haplotype consisting of ERCC1 Asn118Asn(A), ASE-1 G-21A(G), RAI IVS1 A4364G(A) are at increased risk of lung cancer especially among women. Here, we analyse for gene-environment interactions with the predefined haplotype in a case cohort study including 428 lung cancer cases and a comparison group of 800 persons, all from the prospective Diet, Cancer and Health cohort of 57,000 Danes. At high smoking intensity (> 20 g tobacco/day), there was only additional risk of smoking intensity among women who were homozygous carriers of the haplotype (IRR=2.03; 95% CI: 1.10-3.73 per 5 additional g tobacco/day). (c) 2006 Elsevier Ireland Ltd. All rights reserved.
Original languageEnglish
JournalCancer Letters
Publication date2007
Volume247
Issue1
Pages159-165
ISSN0304-3835
DOIs
StatePublished
CitationsWeb of Science® Times Cited: No match on DOI
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