Flow-orthogonal bead oscillation in a microfluidic chip with a magnetic anisotropic flux-guide array

Publication: Research - peer-review › Journal article – Annual report year: 2011

Standard

Flow-orthogonal bead oscillation in a microfluidic chip with a magnetic anisotropic flux-guide array. / Van Pelt, Stijn; Derks, Roy; Matteucci, Marco; Hansen, Mikkel Fougt; Dietzel, Andreas.

In: Biomedical Microdevices, Vol. 13, No. 2, 2011, p. 353-359.

Publication: Research - peer-review › Journal article – Annual report year: 2011

In: Biomedical Microdevices, Vol. 13, No. 2, 2011, p. 353-359.

Publication: Research - peer-review › Journal article – Annual report year: 2011

Bibtex

@article{57aeb551e3e549edaec47b1290648df5,

title = "Flow-orthogonal bead oscillation in a microfluidic chip with a magnetic anisotropic flux-guide array",

publisher = "Springer New York LLC",

author = "{Van Pelt}, Stijn and Roy Derks and Marco Matteucci and Hansen, {Mikkel Fougt} and Andreas Dietzel",

note = "Electronic supplementary material: The online version of this article (doi:10.1007/s10544-010-9503-5) contains supplementary material, which is available to authorized users.",

year = "2011",

volume = "13",

number = "2",

pages = "353--359",

journal = "Biomedical Microdevices",

issn = "1387-2176",

}

RIS

TY - JOUR

T1 - Flow-orthogonal bead oscillation in a microfluidic chip with a magnetic anisotropic flux-guide array

A1 - Van Pelt,Stijn

A1 - Derks,Roy

A1 - Matteucci,Marco

A1 - Hansen,Mikkel Fougt

A1 - Dietzel,Andreas

AU - Van Pelt,Stijn

AU - Derks,Roy

AU - Matteucci,Marco

AU - Hansen,Mikkel Fougt

AU - Dietzel,Andreas

PB - Springer New York LLC

PY - 2011

Y1 - 2011

N2 - A new concept for the manipulation of superparamagnetic beads inside a microfluidic chip is presented in this paper. The concept allows for bead actuation orthogonal to the flow direction inside a microchannel. Basic manipulation functionalities were studied by means of finite element simulations and results were oval-shaped steady state oscillations with bead velocities up to 500 μm/s. The width of the trajectory could be controlled by prescribing external field rotation. Successful verification experiments were performed on a prototype chip fabricated with excimer laser ablation in polycarbonate and electroforming of nickel flux-guides. Bead velocities up to 450 μm/s were measured in a 75 μm wide channel. By prescribing the currents in the external quadrupole magnet, the shape of the bead trajectory could be controlled.

AB - A new concept for the manipulation of superparamagnetic beads inside a microfluidic chip is presented in this paper. The concept allows for bead actuation orthogonal to the flow direction inside a microchannel. Basic manipulation functionalities were studied by means of finite element simulations and results were oval-shaped steady state oscillations with bead velocities up to 500 μm/s. The width of the trajectory could be controlled by prescribing external field rotation. Successful verification experiments were performed on a prototype chip fabricated with excimer laser ablation in polycarbonate and electroforming of nickel flux-guides. Bead velocities up to 450 μm/s were measured in a 75 μm wide channel. By prescribing the currents in the external quadrupole magnet, the shape of the bead trajectory could be controlled.

U2 - 10.1007/s10544-010-9503-5

DO - 10.1007/s10544-010-9503-5

JO - Biomedical Microdevices

JF - Biomedical Microdevices

SN - 1387-2176

IS - 2

VL - 13

SP - 353

EP - 359

ER -