Fish intake, erythrocyte n-3 fatty acid status and metabolic health in Danish adolescent girls and boys

Publication: Research - peer-reviewJournal article – Annual report year: 2011

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Fish intake, erythrocyte n-3 fatty acid status and metabolic health in Danish adolescent girls and boys. / Lauritzen, Lotte; Harsløf, Laurine B. S.; Hellgren, Lars; Pedersen, Maiken Højgaard; Mølgaard, Christian; Michaelsen, Kim F.

In: British Journal of Nutrition, Vol. 107, 2012, p. 697-704.

Publication: Research - peer-reviewJournal article – Annual report year: 2011

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Lauritzen, Lotte; Harsløf, Laurine B. S.; Hellgren, Lars; Pedersen, Maiken Højgaard; Mølgaard, Christian; Michaelsen, Kim F. / Fish intake, erythrocyte n-3 fatty acid status and metabolic health in Danish adolescent girls and boys.

In: British Journal of Nutrition, Vol. 107, 2012, p. 697-704.

Publication: Research - peer-reviewJournal article – Annual report year: 2011

Bibtex

@article{8524e9555af94f20aa8fc69d3721cdfd,
title = "Fish intake, erythrocyte n-3 fatty acid status and metabolic health in Danish adolescent girls and boys",
publisher = "Cambridge University Press",
author = "Lotte Lauritzen and Harsløf, {Laurine B. S.} and Lars Hellgren and Pedersen, {Maiken Højgaard} and Christian Mølgaard and Michaelsen, {Kim F.}",
year = "2012",
doi = "10.1017/S0007114511002418",
volume = "107",
pages = "697--704",
journal = "British Journal of Nutrition",
issn = "0007-1145",

}

RIS

TY - JOUR

T1 - Fish intake, erythrocyte n-3 fatty acid status and metabolic health in Danish adolescent girls and boys

A1 - Lauritzen,Lotte

A1 - Harsløf,Laurine B. S.

A1 - Hellgren,Lars

A1 - Pedersen,Maiken Højgaard

A1 - Mølgaard,Christian

A1 - Michaelsen,Kim F.

AU - Lauritzen,Lotte

AU - Harsløf,Laurine B. S.

AU - Hellgren,Lars

AU - Pedersen,Maiken Højgaard

AU - Mølgaard,Christian

AU - Michaelsen,Kim F.

PB - Cambridge University Press

PY - 2012

Y1 - 2012

N2 - Marine n-3 long-chain PUFA (n-3 LCPUFA) may have a beneficial effect on several aspects of the metabolic syndrome (dyslipidaemia, insulin resistance, hypertension and abdominal obesity). The metabolic syndrome is increasing in prevalence during adolescence, but only few studies have investigated the effects of n-3 LCPUFA in adolescence. The present study examines associations between fish intake (assessed by a 7 d pre-coded food diary), erythrocyte (RBC) DHA status (analysed by GC) and metabolic syndrome measures (anthropometry, blood pressure and plasma lipids, insulin and glucose) in 109 17-year-old children from the Copenhagen Birth Cohort Study. Of the children, 8% were overweight or obese and few showed signs of the metabolic syndrome, but all the metabolic syndrome variables were correlated. Median fish intake was 10·7 (interquartile range 3·6–21·2) g/d. Boys tended to have a higher fish intake (P¼0·052), but girls had significantly higher RBC levels of DHA (P¼0·001). Sex and fish intake explained 37% of the variance in RBC-DHA (P,0·001). After adjusting for confounders, high DHA status was found to be significantly correlated with higher systolic blood pressure (P¼0·014) and increased fasting insulin (P¼0·018), but no adverse association was observed with the mean metabolic syndrome z-score. Overall, the present study showed the expected association between fish intake and RBC-DHA, which in contrast to our expectations tended to be associated with a poorer metabolic profile. Whether these results reflect the physiological function of n-3 LCPUFA, lifestyle factors associated with fish intake in Denmark, or mere chance remains to be investigated.

AB - Marine n-3 long-chain PUFA (n-3 LCPUFA) may have a beneficial effect on several aspects of the metabolic syndrome (dyslipidaemia, insulin resistance, hypertension and abdominal obesity). The metabolic syndrome is increasing in prevalence during adolescence, but only few studies have investigated the effects of n-3 LCPUFA in adolescence. The present study examines associations between fish intake (assessed by a 7 d pre-coded food diary), erythrocyte (RBC) DHA status (analysed by GC) and metabolic syndrome measures (anthropometry, blood pressure and plasma lipids, insulin and glucose) in 109 17-year-old children from the Copenhagen Birth Cohort Study. Of the children, 8% were overweight or obese and few showed signs of the metabolic syndrome, but all the metabolic syndrome variables were correlated. Median fish intake was 10·7 (interquartile range 3·6–21·2) g/d. Boys tended to have a higher fish intake (P¼0·052), but girls had significantly higher RBC levels of DHA (P¼0·001). Sex and fish intake explained 37% of the variance in RBC-DHA (P,0·001). After adjusting for confounders, high DHA status was found to be significantly correlated with higher systolic blood pressure (P¼0·014) and increased fasting insulin (P¼0·018), but no adverse association was observed with the mean metabolic syndrome z-score. Overall, the present study showed the expected association between fish intake and RBC-DHA, which in contrast to our expectations tended to be associated with a poorer metabolic profile. Whether these results reflect the physiological function of n-3 LCPUFA, lifestyle factors associated with fish intake in Denmark, or mere chance remains to be investigated.

KW - n-3 PUFA

KW - Insulin sensitivity

KW - Plasma lipid profile

KW - Blood pressure

UR - http://journals.cambridge.org/abstract_S0007114511002418

U2 - 10.1017/S0007114511002418

DO - 10.1017/S0007114511002418

JO - British Journal of Nutrition

JF - British Journal of Nutrition

SN - 0007-1145

VL - 107

SP - 697

EP - 704

ER -