First introduction of highly pathogenic H5NI avian influenza A viruses in wild and domestic birds in Denmark, Northern Europe

Publication: Research - peer-reviewJournal article – Annual report year: 2007

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@article{82cc5770fff24c0ba6b6e6d33b3fbc0f,
title = "First introduction of highly pathogenic H5NI avian influenza A viruses in wild and domestic birds in Denmark, Northern Europe",
publisher = "BioMed Central Ltd.",
author = "K. Bragstad and Jørgensen, {Poul Henrik} and Kurt Handberg and Hammer, {Anne Sofie} and Susanne Kabell and A. Fomsgaard",
year = "2007",
doi = "10.1186/1743-422X-4-43",
volume = "4",
pages = "43",
journal = "Virology Journal",
issn = "1743-422X",

}

RIS

TY - JOUR

T1 - First introduction of highly pathogenic H5NI avian influenza A viruses in wild and domestic birds in Denmark, Northern Europe

A1 - Bragstad,K.

A1 - Jørgensen,Poul Henrik

A1 - Handberg,Kurt

A1 - Hammer,Anne Sofie

A1 - Kabell,Susanne

A1 - Fomsgaard,A.

AU - Bragstad,K.

AU - Jørgensen,Poul Henrik

AU - Handberg,Kurt

AU - Hammer,Anne Sofie

AU - Kabell,Susanne

AU - Fomsgaard,A.

PB - BioMed Central Ltd.

PY - 2007

Y1 - 2007

N2 - Background: Since 2005 highly pathogenic ( HP) avian influenza A H5N1 viruses have spread from Asia to Africa and Europe infecting poultry, humans and wild birds. HP H5N1 virus was isolated in Denmark for the first time in March 2006. A total of 44 wild birds were found positive for the HP H5N1 infection. In addition, one case was reported in a backyard poultry flock. Results: Full-genome characterisation of nine isolates revealed that the Danish H5N1 viruses were highly similar to German H5N1 isolates in all genes from the same time period. The haemagglutinin gene grouped phylogenetically in H5 clade 2 subclade 2 and closest relatives besides the German isolates were isolates from Croatia in 2005, Nigeria and Niger in 2006 and isolates from Astrakhan in Russia 2006. The German and Danish isolates shared unique substitutions in the NA, PB1 and NS2 proteins. Conclusion: The first case of HP H5N1 infection of wild and domestic birds in Denmark was experienced in March 2006. This is the first full genome characterisation of HP H5N1 avian influenza A virus in the Nordic countries. The Danish viruses from this time period have their origin from the wild bird strains from Qinghai in 2005. These viruses may have been introduced to the Northern Europe through unusual migration due to the cold weather in Eastern Europe at that time.

AB - Background: Since 2005 highly pathogenic ( HP) avian influenza A H5N1 viruses have spread from Asia to Africa and Europe infecting poultry, humans and wild birds. HP H5N1 virus was isolated in Denmark for the first time in March 2006. A total of 44 wild birds were found positive for the HP H5N1 infection. In addition, one case was reported in a backyard poultry flock. Results: Full-genome characterisation of nine isolates revealed that the Danish H5N1 viruses were highly similar to German H5N1 isolates in all genes from the same time period. The haemagglutinin gene grouped phylogenetically in H5 clade 2 subclade 2 and closest relatives besides the German isolates were isolates from Croatia in 2005, Nigeria and Niger in 2006 and isolates from Astrakhan in Russia 2006. The German and Danish isolates shared unique substitutions in the NA, PB1 and NS2 proteins. Conclusion: The first case of HP H5N1 infection of wild and domestic birds in Denmark was experienced in March 2006. This is the first full genome characterisation of HP H5N1 avian influenza A virus in the Nordic countries. The Danish viruses from this time period have their origin from the wild bird strains from Qinghai in 2005. These viruses may have been introduced to the Northern Europe through unusual migration due to the cold weather in Eastern Europe at that time.

U2 - 10.1186/1743-422X-4-43

DO - 10.1186/1743-422X-4-43

JO - Virology Journal

JF - Virology Journal

SN - 1743-422X

VL - 4

SP - 43

ER -