Facile design of biomaterials by 'click' chemistry

Publication: Research - peer-reviewJournal article – Annual report year: 2012

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Facile design of biomaterials by 'click' chemistry. / Hvilsted, Søren.

In: Polymer International, Vol. 61, No. 4, 2012, p. 485-494.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

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Author

Hvilsted, Søren / Facile design of biomaterials by 'click' chemistry.

In: Polymer International, Vol. 61, No. 4, 2012, p. 485-494.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Bibtex

@article{31bc0c54950d46d591eac52929dcf886,
title = "Facile design of biomaterials by 'click' chemistry",
keywords = "Azide–alkyne cycloaddition, Thiol–ene click chemistry, Biomedical materials, Functional surface, Biologically active surfaces, Conducting polymer surfaces",
publisher = "John/Wiley & Sons Ltd.",
author = "Søren Hvilsted",
year = "2012",
doi = "10.1002/pi.4135",
volume = "61",
number = "4",
pages = "485--494",
journal = "Polymer International",
issn = "0959-8103",

}

RIS

TY - JOUR

T1 - Facile design of biomaterials by 'click' chemistry

A1 - Hvilsted,Søren

AU - Hvilsted,Søren

PB - John/Wiley & Sons Ltd.

PY - 2012

Y1 - 2012

N2 - The advent of the so‐called ‘click chemistry’ a decade ago has significantly improved the chemical toolbox for producing novel biomaterials. This review focuses primarily on the application of Cu(I)‐catalysed azide–alkyne 1,3‐cycloadditon in the preparation of numerous, diverse biomaterials and biomedical materials and concepts. In addition, the thiol–ene ‘click’ reaction is addressed in the same manner, and the possibility of using both click reactions orthogonally is highlighted. A strategy for the preparation of novel intriguing poly(ε‐caprolactone)‐based nanobiomaterials by orthogonal click chemistry is elaborated. The present state of creating functional and biologically active surfaces by click chemistry is presented. Finally, conducting surfaces based on an azide‐functionalized polymer with prospective biological sensor potential are introduced. Copyright © 2012 Society of Chemical Industry

AB - The advent of the so‐called ‘click chemistry’ a decade ago has significantly improved the chemical toolbox for producing novel biomaterials. This review focuses primarily on the application of Cu(I)‐catalysed azide–alkyne 1,3‐cycloadditon in the preparation of numerous, diverse biomaterials and biomedical materials and concepts. In addition, the thiol–ene ‘click’ reaction is addressed in the same manner, and the possibility of using both click reactions orthogonally is highlighted. A strategy for the preparation of novel intriguing poly(ε‐caprolactone)‐based nanobiomaterials by orthogonal click chemistry is elaborated. The present state of creating functional and biologically active surfaces by click chemistry is presented. Finally, conducting surfaces based on an azide‐functionalized polymer with prospective biological sensor potential are introduced. Copyright © 2012 Society of Chemical Industry

KW - Azide–alkyne cycloaddition

KW - Thiol–ene click chemistry

KW - Biomedical materials

KW - Functional surface

KW - Biologically active surfaces

KW - Conducting polymer surfaces

U2 - 10.1002/pi.4135

DO - 10.1002/pi.4135

JO - Polymer International

JF - Polymer International

SN - 0959-8103

IS - 4

VL - 61

SP - 485

EP - 494

ER -