European freshwater VHSV genotype Ia isolates divide into two distinct subpopulations

Publication: Research - peer-reviewJournal article – Annual report year: 2012

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@article{90eaf535dd5445319e5b39d7127b317d,
title = "European freshwater VHSV genotype Ia isolates divide into two distinct subpopulations",
keywords = "Viral haemorrhagic septicaemia, Geographic subgroups, Molecular tracing, Genotype Ia-1, Genotype Ia-2, Epidemiology",
publisher = "Inter-Research",
author = "Søren Kahns and Skall, {Helle Frank} and Kaas, {Rolf Sommer} and H. Korsholm and Jensen, {Ann Britt Bang} and Jonstrup, {Søren Peter} and Dodge, {M. J.} and Katja Einer-Jensen and D. Stone and Olesen, {Niels Jørgen}",
year = "2012",
doi = "10.3354/dao02444",
volume = "99",
number = "1",
pages = "23--35",
journal = "Diseases of Aquatic Organisms",
issn = "0177-5103",

}

RIS

TY - JOUR

T1 - European freshwater VHSV genotype Ia isolates divide into two distinct subpopulations

A1 - Kahns,Søren

A1 - Skall,Helle Frank

A1 - Kaas,Rolf Sommer

A1 - Korsholm,H.

A1 - Jensen,Ann Britt Bang

A1 - Jonstrup,Søren Peter

A1 - Dodge,M. J.

A1 - Einer-Jensen,Katja

A1 - Stone,D.

A1 - Olesen,Niels Jørgen

AU - Kahns,Søren

AU - Skall,Helle Frank

AU - Kaas,Rolf Sommer

AU - Korsholm,H.

AU - Jensen,Ann Britt Bang

AU - Jonstrup,Søren Peter

AU - Dodge,M. J.

AU - Einer-Jensen,Katja

AU - Stone,D.

AU - Olesen,Niels Jørgen

PB - Inter-Research

PY - 2012

Y1 - 2012

N2 - Viral haemorrhagic septicaemia (VHS), caused by the novirhabdovirus VHSV, often leads to significant economic losses to European rainbow trout production. The virus isolates are divided into 4 distinct genotypes with additional subgroups including sublineage Ia, isolates of which are the main source of outbreaks in European rainbow trout farming. A significant portion of Danish rainbow trout farms have been considered endemically infected with VHSV since the first disease outbreak was observed in the 1950s. However, following a series of sanitary programs starting in 1965, VHSV has not been detected in Denmark since January 2009. Full-length G-genes of all Danish VHSV isolates that were submitted for diagnostic analyses in the period 2004−2009 were sequenced and analysed. All 58 Danish isolates from rainbow trout grouped with sublineage Ia isolates. Furthermore, VHSV isolates from infected Danish freshwater catchments appear to have evolved into a distinct clade within sublineage Ia, herein designated clade Ia-1, whereas trout isolates originating from other continental European countries cluster in another distinct clade, designated clade Ia-2. In addition, phylogenetic analyses indicate that VHSV Ia-1 strains have caused a few outbreaks in Germany and the UK. It is likely that viruses have been transmitted from infected site(s) out of the Danish environment, although a direct transmission pathway has not been identified. Furthermore, VHSV Ia-2 isolates seem to have been transmitted to Denmark at least once. Interestingly, one viral isolate possibly persisted in a Danish watershed for nearly 4 yr without detection whereas other subclades of VHSV isolates appear to have been eliminated, probably because of implemented eradication procedures.

AB - Viral haemorrhagic septicaemia (VHS), caused by the novirhabdovirus VHSV, often leads to significant economic losses to European rainbow trout production. The virus isolates are divided into 4 distinct genotypes with additional subgroups including sublineage Ia, isolates of which are the main source of outbreaks in European rainbow trout farming. A significant portion of Danish rainbow trout farms have been considered endemically infected with VHSV since the first disease outbreak was observed in the 1950s. However, following a series of sanitary programs starting in 1965, VHSV has not been detected in Denmark since January 2009. Full-length G-genes of all Danish VHSV isolates that were submitted for diagnostic analyses in the period 2004−2009 were sequenced and analysed. All 58 Danish isolates from rainbow trout grouped with sublineage Ia isolates. Furthermore, VHSV isolates from infected Danish freshwater catchments appear to have evolved into a distinct clade within sublineage Ia, herein designated clade Ia-1, whereas trout isolates originating from other continental European countries cluster in another distinct clade, designated clade Ia-2. In addition, phylogenetic analyses indicate that VHSV Ia-1 strains have caused a few outbreaks in Germany and the UK. It is likely that viruses have been transmitted from infected site(s) out of the Danish environment, although a direct transmission pathway has not been identified. Furthermore, VHSV Ia-2 isolates seem to have been transmitted to Denmark at least once. Interestingly, one viral isolate possibly persisted in a Danish watershed for nearly 4 yr without detection whereas other subclades of VHSV isolates appear to have been eliminated, probably because of implemented eradication procedures.

KW - Viral haemorrhagic septicaemia

KW - Geographic subgroups

KW - Molecular tracing

KW - Genotype Ia-1

KW - Genotype Ia-2

KW - Epidemiology

UR - http://www.int-res.com/abstracts/dao/v99/n1/p23-35/

U2 - 10.3354/dao02444

DO - 10.3354/dao02444

JO - Diseases of Aquatic Organisms

JF - Diseases of Aquatic Organisms

SN - 0177-5103

IS - 1

VL - 99

SP - 23

EP - 35

ER -