Established and Emerging Trends in Computational Drug Discovery in the Structural Genomics Era

Publication: Research - peer-reviewJournal article – Annual report year: 2012

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Bioinformatics and chemoinformatics approaches contribute to hit discovery, hit-to-lead optimization, safety profiling, and target identification and enhance our overall understanding of the health and disease states. A vast repertoire of computational methods has been reported and increasingly combined in order to address more and more challenging targets or complex molecular mechanisms in the context of large-scale integration of structure and bioactivity data produced by private and public drug research. This review explores some key computational methods directly linked to drug discovery and chemical biology with a special emphasis on compound collection preparation, virtual screening, protein docking, and systems pharmacology. A list of generally freely available software packages and online resources is provided, and examples of successful applications are briefly commented upon.
Original languageEnglish
JournalChemistry & Biology
Publication date2012
Volume19
Issue1
Pages29-41
ISSN1074-5521
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 24
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