Ependymal cilia beating induces an actin network to protect centrioles against shear stress

Publication: Research - peer-reviewJournal article – Annual report year: 2018

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  • Author: Mahuzier, Alexia

    Universite Paris 13, France

  • Author: Shihavuddin, Asm

    Image Analysis & Computer Graphics, Department of Applied Mathematics and Computer Science , Technical University of Denmark, Richard Petersens Plads, 2800, Kgs. Lyngby, Denmark

  • Author: Fournier, Clémence

    CNRS Centre National de la Recherche Scientifique, France

  • Author: Lansade, Pauline

    Universite Paris 13, France

  • Author: Faucourt, Marion

    Universite Paris 13, France

  • Author: Menezes, Nikita

    Universite Paris 13, France

  • Author: Meunier, Alice

    Universite Paris 13, France

  • Author: Garfa-Traoré, Meriem

    Universite Paris Sorbonne - Paris IV, France

  • Author: Carlier, Marie France

    CNRS Centre National de la Recherche Scientifique, France

  • Author: Voituriez, Raphael

    CNRS Centre National de la Recherche Scientifique, France

  • Author: Genovesio, Auguste

    Universite Paris 13, France

  • Author: Spassky, Nathalie

    Universite Paris 13, France

  • Author: Delgehyr, Nathalie

    Universite Paris 13, France

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Multiciliated ependymal cells line all brain cavities. The beating of their motile cilia contributes to the flow of cerebrospinal fluid, which is required for brain homoeostasis and functions. Motile cilia, nucleated from centrioles, persist once formed and withstand the forces produced by the external fluid flow and by their own cilia beating. Here, we show that a dense actin network around the centrioles is induced by cilia beating, as shown by the disorganisation of the actin network upon impairment of cilia motility. Moreover, disruption of the actin network, or specifically of the apical actin network, causes motile cilia and their centrioles to detach from the apical surface of ependymal cell. In conclusion, cilia beating controls the apical actin network around centrioles; the mechanical resistance of this actin network contributes, in turn, to centriole stability.

Original languageEnglish
Article number2279
JournalNature Communications
Volume9
Issue number1
Number of pages15
ISSN2041-1723
DOIs
StatePublished - 1 Dec 2018
CitationsWeb of Science® Times Cited: 0
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