Enterotypes of the human gut microbiome

Publication: Research - peer-review › Journal article – Annual report year: 2011

DOI

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By the same authors

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    European Molecular Biology Laboratory

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    European Molecular Biology Laboratory

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    Commissariat à l’Energie Atomique

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    Commissariat à l’Energie Atomique

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    European Molecular Biology Laboratory

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    European Molecular Biology Laboratory

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    European Molecular Biology Laboratory

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    European Molecular Biology Laboratory

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    Commissariat à l’Energie Atomique

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    Institut National de la Recherche Agronomique

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    Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Kemitorvet, 2800, Kgs. Lyngby

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    University Hospital Vall d’Hebron, Digestive System Research Unit

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    University Hospital Vall d’Hebron, Digestive System Research Unit

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    Barcelona Supercomputing Center

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    Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Kemitorvet, 2800, Kongens Lyngby

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    University of Copenhagen, Faculty of Health Sciences

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    The University of Tokyo Kashiwa Campus, Computational Biology Laboratory Bld

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    University of Miyazaki, Frontier Science Research Center

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    Wageningen University, Laboratory of Microbiology

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    Tokyo Institute of Technology, Graduate School of Bioscience and Biotechnology

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    Institut National de la Recherche Agronomique

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    Institut National de la Recherche Agronomique

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    University Hospital Vall d’Hebron, Digestive System Research Unit

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    Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Kemitorvet, 2800, Lyngby

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    University of Copenhagen, Faculty of Health Science

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    Institut National de la Recherche Agronomique

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    Commissariat à l’Energie Atomique

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    BGI-Shenzhen

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    CFB - Metagenomic Systems Biology, Novo Nordisk Foundation Center for Biosustainability, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Kemitorvet, 2800, Lyngby

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    Wageningen University, Laboratory of Microbiology

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    Barcelona Supercomputing Center

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    Commissariat à l’Energie Atomique

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    Wageningen University, Laboratory of Microbiology

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    BGI-Shenzhen

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    University Hospital Vall d’Hebron, Digestive System Research Unit

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    University of Copenhagen, Faculty of Health Sciences,

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    Wageningen University, Laboratory of Microbiology

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    Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Kemitorvet, 2800, Lyngby

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    Institut National de la Recherche Agronomique

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    University Hospital Vall d’Hebron, Digestive System Research Unit

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    Commissariat à l’Energie Atomique

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    Institut National de la Recherche Agronomique

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    Institut National de la Recherche Agronomique

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    Institut Mérieux

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    UCB Pharma SA

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    Danone Research

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    Institut National de la Recherche Agronomique

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    Institut National de la Recherche Agronomique

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    Danone Research

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    Institut National de la Recherche Agronomique

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    European Molecular Biology Laboratory

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    Technical University of Denmark, Center for Biological Sequence Analysis

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    Institut National de la Recherche Agronomique

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    Institut National de la Recherche Agronomique

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    Institut National de la Recherche Agronomique

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    European Molecular Biology Laboratory

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    Danone Research

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    Institut National de la Recherche Agronomique

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    Institut National de la Recherche Agronomique

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    Institut National de la Recherche Agronomique

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    Danone Research

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    Institut National de la Recherche Agronomique

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    Institut National de la Recherche Agronomique

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    Institut National de la Recherche Agronomique

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    Institut National de la Recherche Agronomique

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    Institut Mérieux

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    Commissariat à l’Energie Atomique

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    Institut Mérieux

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    University of Strasbourg, INSERM

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    Danone Research

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    The Wellcome Trust Sanger Institute

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    Institut National de la Recherche Agronomique

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    Istituto Europeo di Oncologia

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    Institut National de la Recherche Agronomique

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    European Molecular Biology Laboratory

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    University Hospital Vall d’Hebron, Digestive System Research Unit

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    The Wellcome Trust Sanger Institute

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    Institut National de la Recherche Agronomique

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    University Hospital Vall d’Hebron, Digestive System Research Unit

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    Institut National de la Recherche Agronomique

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    European Molecular Biology Laboratory

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    Commissariat à l’Energie Atomique

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    Institut National de la Recherche Agronomique

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    European Molecular Biology Laboratory

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Our knowledge of species and functional composition of the human gut microbiome is rapidly increasing, but it is still based on very few cohorts and little is known about variation across the world. By combining 22 newly sequenced faecal metagenomes of individuals from four countries with previously published data sets, here we identify three robust clusters (referred to as enterotypes hereafter) that are not nation or continent specific. We also confirmed the enterotypes in two published, larger cohorts, indicating that intestinal microbiota variation is generally stratified, not continuous. This indicates further the existence of a limited number of well-balanced host-microbial symbiotic states that might respond differently to diet and drug intake. The enterotypes are mostly driven by species composition, but abundant molecular functions are not necessarily provided by abundant species, highlighting the importance of a functional analysis to understand microbial communities. Although individual host properties such as body mass index, age, or gender cannot explain the observed enterotypes, data-driven marker genes or functional modules can be identified for each of these host properties. For example, twelve genes significantly correlate with age and three functional modules with the body mass index, hinting at a diagnostic potential of microbial markers.
Original languageEnglish
JournalNature
Publication date2011
Volume473
Journal number7346
Pages174-180
ISSN0028-0836
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 375

ID: 5631528

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