Engineered mammalian cells for production of recombinant proteins

Publication: ResearchPatent – Annual report year: 2017

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The present invention relates to mammalian cells modified to provide for improved expression of a recombinant protein of interest. In particular, the invention relates to CHO cells and other host cells in which the expression of one or more endogenous secreted proteins has been disrupted, as well as to the preparation, identification and use of such cells in the production of recombinant proteins.

Original languageEnglish
IPCC07K 14/ 78 A I
Patent numberWO2017186671
Date02/11/2017
CountryInternational Bureau of the World Intellectual Property Organization (WIPO)
StatePublished - 2 Nov 2017
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