Electrospun polyvinyl-alcohol nanofibers as oral fast-dissolving delivery system of caffeine and riboflavin
Publication: Research - peer-review › Journal article – Annual report year: 2013
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Electrospun polyvinyl-alcohol nanofibers as oral fast-dissolving delivery system of caffeine and riboflavin. / Li, Xiaoqiang; Kanjwal, Muzafar Ahmed; Lin, Lin; Chronakis, Ioannis S.
In: Colloids and Surfaces B: Biointerfaces, Vol. 103, 2013, p. 182-188.Publication: Research - peer-review › Journal article – Annual report year: 2013
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TY - JOUR
T1 - Electrospun polyvinyl-alcohol nanofibers as oral fast-dissolving delivery system of caffeine and riboflavin
A1 - Li,Xiaoqiang
A1 - Kanjwal,Muzafar Ahmed
A1 - Lin,Lin
A1 - Chronakis,Ioannis S.
AU - Li,Xiaoqiang
AU - Kanjwal,Muzafar Ahmed
AU - Lin,Lin
AU - Chronakis,Ioannis S.
PB - Elsevier BV
PY - 2013
Y1 - 2013
N2 - Fast-dissolving drug delivery systems were prepared by electrospinning using polyvinyl alcohol (PVA) as the filament-forming polymer and drug carrier. Caffeine and riboflavin were used as the model drugs. Scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) and X-ray diffraction were applied to investigate the physicochemical properties of electrospun nanofibers. The SEM images showed that nanofibers prepared from electrospinning PVA/drug aqueous solutions possessed an ultrafine morphology with an average diameter in the range of 260-370 nm. Pharmacotechnical tests showed that PVA/caffeine and PVA/riboflavin nanofibrous mats had almost the same dissolution time (about 1.5 s) and wetting time (about 4.5 s). The release measurements indicated that drugs can be released in a burst manner (caffeine to an extent of 100% and riboflavin to an extent of 40% within 60 s) from the PVA nanofibrous matrices.
AB - Fast-dissolving drug delivery systems were prepared by electrospinning using polyvinyl alcohol (PVA) as the filament-forming polymer and drug carrier. Caffeine and riboflavin were used as the model drugs. Scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) and X-ray diffraction were applied to investigate the physicochemical properties of electrospun nanofibers. The SEM images showed that nanofibers prepared from electrospinning PVA/drug aqueous solutions possessed an ultrafine morphology with an average diameter in the range of 260-370 nm. Pharmacotechnical tests showed that PVA/caffeine and PVA/riboflavin nanofibrous mats had almost the same dissolution time (about 1.5 s) and wetting time (about 4.5 s). The release measurements indicated that drugs can be released in a burst manner (caffeine to an extent of 100% and riboflavin to an extent of 40% within 60 s) from the PVA nanofibrous matrices.
U2 - 10.1016/j.colsurfb.2012.10.016
DO - 10.1016/j.colsurfb.2012.10.016
JO - Colloids and Surfaces B: Biointerfaces
JF - Colloids and Surfaces B: Biointerfaces
SN - 0927-7765
VL - 103
SP - 182
EP - 188
ER -