Electrospun polyvinyl-alcohol nanofibers as oral fast-dissolving delivery system of caffeine and riboflavin

Publication: Research - peer-reviewJournal article – Annual report year: 2013

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@article{064f102d6a694c97b0d966c62a1509aa,
title = "Electrospun polyvinyl-alcohol nanofibers as oral fast-dissolving delivery system of caffeine and riboflavin",
publisher = "Elsevier BV",
author = "Xiaoqiang Li and Kanjwal, {Muzafar Ahmed} and Lin Lin and Chronakis, {Ioannis S.}",
year = "2013",
doi = "10.1016/j.colsurfb.2012.10.016",
volume = "103",
pages = "182--188",
journal = "Colloids and Surfaces B: Biointerfaces",
issn = "0927-7765",

}

RIS

TY - JOUR

T1 - Electrospun polyvinyl-alcohol nanofibers as oral fast-dissolving delivery system of caffeine and riboflavin

A1 - Li,Xiaoqiang

A1 - Kanjwal,Muzafar Ahmed

A1 - Lin,Lin

A1 - Chronakis,Ioannis S.

AU - Li,Xiaoqiang

AU - Kanjwal,Muzafar Ahmed

AU - Lin,Lin

AU - Chronakis,Ioannis S.

PB - Elsevier BV

PY - 2013

Y1 - 2013

N2 - Fast-dissolving drug delivery systems were prepared by electrospinning using polyvinyl alcohol (PVA) as the filament-forming polymer and drug carrier. Caffeine and riboflavin were used as the model drugs. Scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) and X-ray diffraction were applied to investigate the physicochemical properties of electrospun nanofibers. The SEM images showed that nanofibers prepared from electrospinning PVA/drug aqueous solutions possessed an ultrafine morphology with an average diameter in the range of 260-370 nm. Pharmacotechnical tests showed that PVA/caffeine and PVA/riboflavin nanofibrous mats had almost the same dissolution time (about 1.5 s) and wetting time (about 4.5 s). The release measurements indicated that drugs can be released in a burst manner (caffeine to an extent of 100% and riboflavin to an extent of 40% within 60 s) from the PVA nanofibrous matrices.

AB - Fast-dissolving drug delivery systems were prepared by electrospinning using polyvinyl alcohol (PVA) as the filament-forming polymer and drug carrier. Caffeine and riboflavin were used as the model drugs. Scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) and X-ray diffraction were applied to investigate the physicochemical properties of electrospun nanofibers. The SEM images showed that nanofibers prepared from electrospinning PVA/drug aqueous solutions possessed an ultrafine morphology with an average diameter in the range of 260-370 nm. Pharmacotechnical tests showed that PVA/caffeine and PVA/riboflavin nanofibrous mats had almost the same dissolution time (about 1.5 s) and wetting time (about 4.5 s). The release measurements indicated that drugs can be released in a burst manner (caffeine to an extent of 100% and riboflavin to an extent of 40% within 60 s) from the PVA nanofibrous matrices.

U2 - 10.1016/j.colsurfb.2012.10.016

DO - 10.1016/j.colsurfb.2012.10.016

JO - Colloids and Surfaces B: Biointerfaces

JF - Colloids and Surfaces B: Biointerfaces

SN - 0927-7765

VL - 103

SP - 182

EP - 188

ER -