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Electrochemistry and in situ scanning tunnelling microscopy of pure and redox-marked DNA- and UNA-based oligonucleotides on Au(111)-electrode surfaces. / Hansen, Allan Glargaard; Salvatore, Princia; Karlsen, K.; Nichols, R.; Wengel, Jesper; Ulstrup, Jens.

In: Physical Chemistry Chemical Physics, Vol. 15, No. 3, 2013, p. 776-786.

Publication: Research - peer-reviewJournal article – Annual report year: 2013

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Hansen, Allan Glargaard; Salvatore, Princia; Karlsen, K.; Nichols, R.; Wengel, Jesper; Ulstrup, Jens / Electrochemistry and in situ scanning tunnelling microscopy of pure and redox-marked DNA- and UNA-based oligonucleotides on Au(111)-electrode surfaces.

In: Physical Chemistry Chemical Physics, Vol. 15, No. 3, 2013, p. 776-786.

Publication: Research - peer-reviewJournal article – Annual report year: 2013

Bibtex

@article{71d329f7d8184f489ec3daceb45cd895,
title = "Electrochemistry and in situ scanning tunnelling microscopy of pure and redox-marked DNA- and UNA-based oligonucleotides on Au(111)-electrode surfaces",
publisher = "Royal Society of Chemistry",
author = "Hansen, {Allan Glargaard} and Princia Salvatore and K. Karlsen and R. Nichols and Jesper Wengel and Jens Ulstrup",
note = "Electronic supplementary information (ESI) available: Details of the synthesis and purification of the ONs; MALDI-MS spectra of the oligonucleotides; tunnelling STS of the Ru-derivative of terpy 15-base ss DNA; formalism of STS bandwidth dependence of the ionic strength. See DOI: 10.1039/c2cp42351k",
year = "2013",
doi = "10.1039/c2cp42351k",
volume = "15",
number = "3",
pages = "776--786",
journal = "Physical Chemistry Chemical Physics",
issn = "1463-9076",

}

RIS

TY - JOUR

T1 - Electrochemistry and in situ scanning tunnelling microscopy of pure and redox-marked DNA- and UNA-based oligonucleotides on Au(111)-electrode surfaces

A1 - Hansen,Allan Glargaard

A1 - Salvatore,Princia

A1 - Karlsen,K.

A1 - Nichols,R.

A1 - Wengel,Jesper

A1 - Ulstrup,Jens

AU - Hansen,Allan Glargaard

AU - Salvatore,Princia

AU - Karlsen,K.

AU - Nichols,R.

AU - Wengel,Jesper

AU - Ulstrup,Jens

PB - Royal Society of Chemistry

PY - 2013

Y1 - 2013

N2 - We have studied adsorption and electrochemical electron transfer of several 13- and 15-base DNA and UNA (unlocked nucleic acids) oligonucleotides (ONs) linked to Au(111)-electrode surfaces via a 50-C6-SH group using cyclic voltammetry (CV) and scanning tunnelling microscopy in aqueous buffer under electrochemical potential control (in situ STM). 2,20,60,200-Terpyridine (terpy) onto which the transition metal ions Fe2+/3+, Os2+/3+ and Ru2+/3+ could be coordinated after UNA monolayer formation was attached to UNA via a flexible linker. The metal centres offer CV probes and in situ STM contrast markers, and the flexible UNA/linker a potential binder for intercalation. CV of pure and mercaptohexanol diluted ON monolayers displayed reductive desorption signals but also, presumably capacitive, signals at higher potentials. Distinct voltammetric signals arise on metal binding. Those from Ru-binding are by far the<br/>strongest and in accord with multiple site Ru-attachment. In situ STM disclosed molecular scale features in varying coverage on addition of the metal ions. The Ru-derivatives showed a bias voltage dependent broad maximum in the tunnelling current–overpotential correlation which could be correlated with theoretical frames for condensed matter conductivity of redox molecules. Together the data suggest that Ru-units are bound to both terpy and the UNA–DNA backbone.

AB - We have studied adsorption and electrochemical electron transfer of several 13- and 15-base DNA and UNA (unlocked nucleic acids) oligonucleotides (ONs) linked to Au(111)-electrode surfaces via a 50-C6-SH group using cyclic voltammetry (CV) and scanning tunnelling microscopy in aqueous buffer under electrochemical potential control (in situ STM). 2,20,60,200-Terpyridine (terpy) onto which the transition metal ions Fe2+/3+, Os2+/3+ and Ru2+/3+ could be coordinated after UNA monolayer formation was attached to UNA via a flexible linker. The metal centres offer CV probes and in situ STM contrast markers, and the flexible UNA/linker a potential binder for intercalation. CV of pure and mercaptohexanol diluted ON monolayers displayed reductive desorption signals but also, presumably capacitive, signals at higher potentials. Distinct voltammetric signals arise on metal binding. Those from Ru-binding are by far the<br/>strongest and in accord with multiple site Ru-attachment. In situ STM disclosed molecular scale features in varying coverage on addition of the metal ions. The Ru-derivatives showed a bias voltage dependent broad maximum in the tunnelling current–overpotential correlation which could be correlated with theoretical frames for condensed matter conductivity of redox molecules. Together the data suggest that Ru-units are bound to both terpy and the UNA–DNA backbone.

U2 - 10.1039/c2cp42351k

DO - 10.1039/c2cp42351k

JO - Physical Chemistry Chemical Physics

JF - Physical Chemistry Chemical Physics

SN - 1463-9076

IS - 3

VL - 15

SP - 776

EP - 786

ER -