Effects of network resolution on topological properties of human neocortex

Publication: Research - peer-reviewJournal article – Annual report year: 2012

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Effects of network resolution on topological properties of human neocortex. / Romero-Garcia, Rafael; Atienza, Mercedes; Clemmensen, Line Katrine Harder; Cantero, Jose L.

In: NeuroImage, Vol. 59, No. 4, 2012, p. 3522-3532.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

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Romero-Garcia, Rafael; Atienza, Mercedes; Clemmensen, Line Katrine Harder; Cantero, Jose L. / Effects of network resolution on topological properties of human neocortex.

In: NeuroImage, Vol. 59, No. 4, 2012, p. 3522-3532.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Bibtex

@article{1625626768024d61be6cdafdbc3ee7eb,
title = "Effects of network resolution on topological properties of human neocortex",
publisher = "Academic Press",
author = "Rafael Romero-Garcia and Mercedes Atienza and Clemmensen, {Line Katrine Harder} and Cantero, {Jose L.}",
note = "NOTICE: the attached postprint is the author’s version of a work that was accepted for publication in NeuroImage. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in the document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in NeuroImage, [Volume 59, Issue 4, 15 February 2012] 10.1016/j.neuroimage.2011.10.086",
year = "2012",
doi = "10.1016/j.neuroimage.2011.10.086",
volume = "59",
number = "4",
pages = "3522--3532",
journal = "NeuroImage",
issn = "1053-8119",

}

RIS

TY - JOUR

T1 - Effects of network resolution on topological properties of human neocortex

A1 - Romero-Garcia,Rafael

A1 - Atienza,Mercedes

A1 - Clemmensen,Line Katrine Harder

A1 - Cantero,Jose L.

AU - Romero-Garcia,Rafael

AU - Atienza,Mercedes

AU - Clemmensen,Line Katrine Harder

AU - Cantero,Jose L.

PB - Academic Press

PY - 2012

Y1 - 2012

N2 - Graph theoretical analyses applied to neuroimaging datasets have provided valuable insights into the large-scale anatomical organization of the human neocortex. Most of these studies were performed with different cortical scales leading to cortical networks with different levels of small-world organization. The present study investigates how resolution of thickness-based cortical scales impacts on topological properties of human anatomical cortical networks. To this end, we designed a novel approach aimed at determining the best trade-off between small-world attributes of anatomical cortical networks and the number of cortical regions included in the scale. Results revealed that schemes comprising 540–599 regions (surface areas spanning between 250 and 275mm2) at sparsities below 10% showed a superior balance between small-world organization and the size of the cortical scale employed. Furthermore, we found that the cortical scale representing the best trade-off (599 regions) was more resilient to targeted attacks than atlas-based schemes (Desikan–Killiany atlas, 66 regions) and, most importantly, it did not differ that much from the finest cortical scale tested in the present study (1494 regions). In summary, our study confirms that topological organization of anatomical cortical networks varies with both sparsity and resolution of cortical scale, and it further provides a novel methodological framework aimed at identifying cortical schemes that maximize small-worldness with the lowest scale resolution possible.

AB - Graph theoretical analyses applied to neuroimaging datasets have provided valuable insights into the large-scale anatomical organization of the human neocortex. Most of these studies were performed with different cortical scales leading to cortical networks with different levels of small-world organization. The present study investigates how resolution of thickness-based cortical scales impacts on topological properties of human anatomical cortical networks. To this end, we designed a novel approach aimed at determining the best trade-off between small-world attributes of anatomical cortical networks and the number of cortical regions included in the scale. Results revealed that schemes comprising 540–599 regions (surface areas spanning between 250 and 275mm2) at sparsities below 10% showed a superior balance between small-world organization and the size of the cortical scale employed. Furthermore, we found that the cortical scale representing the best trade-off (599 regions) was more resilient to targeted attacks than atlas-based schemes (Desikan–Killiany atlas, 66 regions) and, most importantly, it did not differ that much from the finest cortical scale tested in the present study (1494 regions). In summary, our study confirms that topological organization of anatomical cortical networks varies with both sparsity and resolution of cortical scale, and it further provides a novel methodological framework aimed at identifying cortical schemes that maximize small-worldness with the lowest scale resolution possible.

KW - Cortical scale

KW - Cortical thickness

KW - Small-world properties

KW - Cortical networks

KW - Structural connectivity

U2 - 10.1016/j.neuroimage.2011.10.086

DO - 10.1016/j.neuroimage.2011.10.086

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

IS - 4

VL - 59

SP - 3522

EP - 3532

ER -