Effects of menopause and high-intensity training on insulin sensitivity and muscle metabolism

Research output: Research - peer-reviewJournal article – Annual report year: 2018

  • Author: Mandrup Jensen, Camilla Maria

    University of Copenhagen, Denmark

  • Author: Egelund, Jon

    University of Copenhagen, Denmark

  • Author: Nyberg, Michael

    University of Copenhagen, Denmark

  • Author: Enevoldsen, Lotte Hahn

    University of Copenhagen, Denmark

  • Author: Kjær, Andreas

    University of Copenhagen, Denmark

  • Author: Clemmensen, Andreas E.

    University of Copenhagen, Denmark

  • Author: Christensen, Anders Nymark

    Image Analysis & Computer Graphics, Department of Applied Mathematics and Computer Science , Technical University of Denmark, Richard Petersens Plads, 2800, Kgs. Lyngby, Denmark

  • Author: Suetta, Charlotte

    University of Copenhagen, Denmark

  • Author: Frikke-Schmidt, Ruth

    University of Copenhagen, Denmark

  • Author: Steenberg, Dorte Enggaard

    University of Copenhagen, Denmark

  • Author: Wojtaszewski, Jørgen F P

    University of Copenhagen, Denmark

  • Author: Hellsten, Ylva

    University of Copenhagen, Denmark

  • Author: Stallknecht, Bente M

    University of Copenhagen, Denmark

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To investigate peripheral insulin sensitivity and skeletal muscle glucose metabolism in premenopausal and postmenopausal women, and evaluate whether exercise training benefits are maintained after menopause. Sedentary, healthy, normal-weight, late premenopausal (n = 21), and early postmenopausal (n = 20) women were included in a 3-month high-intensity exercise training intervention. Body composition was assessed by magnetic resonance imaging and dual-energy x-ray absorptiometry, whole body glucose disposal rate (GDR) by hyperinsulinemic euglycemic clamp (40 mU/m/min), and femoral muscle glucose uptake by positron emission tomography/computed tomography, using the glucose analog fluorodeoxyglucose, expressed as estimated metabolic rate (eMR). Insulin signaling was investigated in muscle biopsies. Age difference between groups was 4.5 years, and no difference was observed in body composition. Training increased lean body mass (estimate [95% confidence interval] 0.5 [0.2-0.9] kg, P 
Original languageEnglish
JournalMenopause
Volume25
Issue number2
Number of pages11
ISSN1072-3714
DOIs
StatePublished - 2018
CitationsWeb of Science® Times Cited: 0

    Research areas

  • Glucose disposal, Insulin sensitivity, Insulin signaling, Menopause, Physical activity, Journal Article
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