Effect of industrially produced trans fat on markers of systemic inflammation: evidence from a randomized trial in women

Publication: Research - peer-reviewJournal article – Annual report year: 2011

  • Author: Bendsen, Nathalie T.

    University of Copenhagen

  • Author: Stender, Steen

    Copenhagen University Hospital

  • Author: Szecsi, Pal B.

    Copenhagen University Hospital

  • Author: Pedersen, Steen B.

    Gentofte University Hospital

  • Author: Basu, Samar

    Uppsala University

  • Author: Hellgren, Lars

    Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark

  • Author: Newman, John W.

    United States Department of Agriculture

  • Author: Larsen, Thomas M.

    University of Copenhagen

  • Author: Haugaard, Steen B.

    Copenhagen University Hospital

  • Author: Astrup, Arne

    University of Copenhagen

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Consumption of industrially produced trans fatty acids (IP-TFA) has been positively associated with systemic markers of low-grade inflammation and endothelial dysfunction in cross-sectional studies, but results from intervention studies are inconclusive. Therefore, we conducted a 16 week double-blind parallel intervention study with the objective to examine the effect of IP-TFA intake on biomarkers of inflammation, oxidative stress, and endothelial dysfunction. Fifty-two healthy overweight postmenopausal women (49 completers) were randomly assigned to receive either partially hydrogenated soybean oil (15.7 g/day IP-TFA) or control oil without IP-TFA. After 16 weeks, IP-TFA intake increased baseline-adjusted serum tumor necrosis factor (TNF) α by 12% [95% confidence interval (CI): 5–20; P = 0.002] more in the IP-TFA group compared with controls. Plasma soluble TNF receptors 1 and 2 were also increased by IP-TFA [155 pg/ml (CI: 63–247); P <0.001 and 480 pg/ml (CI: 72–887); P = 0.02, respectively]. Serum C-reactive protein, interleukin (IL) 6 and adiponectin and subcutaneous abdominal adipose tissue mRNA expression of IL6, IL8, TNFα, and adiponectin as well as ceramide content were not affected by IP-TFA, nor was urinary 8-iso-prostaglandin-F2α. In conclusion, this dietary trial indicates that the mechanisms linking dietary IP-TFA to cardiovascular disease may involve activation of the TNFα system.
Original languageEnglish
JournalJournal of Lipid Research
Issue number10
Pages (from-to)1821-1828
StatePublished - 2011
CitationsWeb of Science® Times Cited: 31


  • Subcutaneous adipose tissue, Dietary intervention, Ceramide, Oxidative stress, Fatty acids
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ID: 5787348