• Author: Axelsen, Mette Bjørndal

    Copenhagen University Hospital, Denmark

  • Author: Stoltenberg, M.

    Copenhagen University Hospital, Denmark

  • Author: Poggenborg, R.

    Copenhagen University Hospital, Denmark

  • Author: Kubassova, O.

    Image Analysis Ltd., United Kingdom

  • Author: Boesen, M.

    Copenhagen University Hospital, Denmark

  • Author: Bliddal, H.

    Copenhagen University Hospital, Denmark

  • Author: Hørslev-Petersen, K.

    King Christian X Hospital for Rheumatic Diseases, Denmark

  • Author: Hanson, Lars G.

    Biomedical Engineering, Department of Electrical Engineering, Technical University of Denmark, Ørsteds Plads, 2800, Kgs. Lyngby, Denmark

  • Author: Østergaard, M.

    Copenhagen University Hospital, Denmark

View graph of relations

Objective: To determine whether dynamic contrast-enhanced magnetic resonance
imaging (DCE-MRI) evaluated using semi-automatic image processing software
can accurately assess synovial inflammation in rheumatoid arthritis (RA) knee
joints. Methods: In 17 RA patients undergoing knee surgery, the average grade of
histological synovial inflammation was determined from four biopsies obtained
during surgery. A preoperative series of T(1)-weighted dynamic fast low-angle shot
(FLASH) MR images was obtained. Parameters characterizing contrast uptake
dynamics, including the initial rate of enhancement (IRE), were generated by the
software in three different areas: (I) the entire slice (Whole slice); (II) a manually
outlined region of interest (ROI) drawn quickly around the joint, omitting large
artefacts such as blood vessels (Quick ROI); and (III) a manually outlined ROI
following the synovial capsule of the knee joint (Precise ROI). Intra- and interreader
agreement was assessed using the intra-class correlation coefficient (ICC).
Results: The IRE from the Quick ROI and the Precise ROI revealed high
correlations to the grade of histological inflammation (Spearman's correlation
coefficient (rho) = 0.70, p = 0.001 and rho = 0.74, p = 0.001, respectively). Intraand
inter-reader ICCs were very high (0.93-1.00). No Whole slice parameters
were correlated to histology. Conclusion: DCE-MRI provides fast and accurate
assessment of synovial inflammation in RA patients. Manual outlining of the joint
to omit large artefacts is necessary.
Original languageEnglish
JournalScandinavian Journal of Rheumatology
Issue number2
Pages (from-to)89-94
StatePublished - 2012
CitationsWeb of Science® Times Cited: 39
Download as:
Download as PDF
Select render style:
Download as HTML
Select render style:
Download as Word
Select render style:

ID: 7652621