Drug Delivery by an Enzyme-Mediated Cyclization of a Lipid Prodrug with Unique Bilayer-Formation Properties

Publication: Research - peer-reviewJournal article – Annual report year: 2009

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Special delivery: Liposomal drug-delivery systems in which prodrugs are activated specifically by disease-associated enzymes have great potential for the treatment of severe diseases, such as cancer. A new type of phospholipid-based prodrug has the ability to form stable small unilamellar vesicles (see picture). Activation of the prodrug vesicles by the enzyme sPLA2 initiates a cyclization reaction, which leads to the release of the drug.
Original languageEnglish
JournalAngewandte Chemie - International Edition
Publication date2009
Volume48
Journal number10
Pages1823-1826
ISSN1433-7851
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 21

Keywords

  • cyclization, prodrugs, liposomes, drug delivery, phospholipase
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