Discovery and Assesment of New Target Sites for Anti-HIV Therapies
Publication: Research › Sound/Visual production (digital) – Annual report year: 2008
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Discovery and Assesment of New Target Sites for Anti-HIV Therapies. / Breward, Chris (Author); Heffernan, Jane (Author); Robert M., Miura (Author); Madras, Neal (Author); Ockendon, John (Author); Sørensen, Mads Peter (Author); Anderssen, Robert (Author); Melnik, Roderick (Author); McGuinness, Mark (Author); Qazi, Sanjive (Author).
2008. Fields-MITACS Industrial Problem-Solving Workshop, University of Toronto, Canada, 11-15 August, 2008., 01-01-08.Publication: Research › Sound/Visual production (digital) – Annual report year: 2008
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TY - ADVS
T1 - Discovery and Assesment of New Target Sites for Anti-HIV Therapies
A2 - Breward,Chris
A2 - Heffernan,Jane
A2 - Robert M.,Miura
A2 - Madras,Neal
A2 - Ockendon,John
A2 - Sørensen,Mads Peter
A2 - Anderssen,Robert
A2 - Melnik,Roderick
A2 - McGuinness,Mark
A2 - Qazi,Sanjive
ED - Breward,Chris
ED - Heffernan,Jane
ED - Robert M.,Miura
ED - Madras,Neal
ED - Ockendon,John
ED - Sørensen,Mads Peter
ED - Anderssen,Robert
ED - Melnik,Roderick
ED - McGuinness,Mark
ED - Qazi,Sanjive
PY - 2008
Y1 - 2008
N2 - The HIV viruses infect cells by endocytosis and takes over parts of the cells reaction pathways in order to reproduce itself and spread the infection. One such pathway is the mammalian inflammatory signaling, which invoke NF-κB as the principal transcription factor. A treatment against HIV could be based on blocking the NF-κB pathway by a suitably designed drug. The aim of the current project is to investigate the feasibility of this idea by using mathematical modelling of the NF-κB pathway.
AB - The HIV viruses infect cells by endocytosis and takes over parts of the cells reaction pathways in order to reproduce itself and spread the infection. One such pathway is the mammalian inflammatory signaling, which invoke NF-κB as the principal transcription factor. A treatment against HIV could be based on blocking the NF-κB pathway by a suitably designed drug. The aim of the current project is to investigate the feasibility of this idea by using mathematical modelling of the NF-κB pathway.
KW - HIV therapies
KW - Nonlinear models of bio systems
KW - Inflamatory pathway
ER -