Discovery and Assesment of New Target Sites for Anti-HIV Therapies

Publication: ResearchSound/Visual production (digital) – Annual report year: 2008

Documents

  • Author: Breward, Chris

    University of Oxford

  • Author: Heffernan, Jane

    York University, Canada

  • Author: Robert M., Miura

    New Jersey Institute of Technology, NJ, USA

  • Author: Madras, Neal

    York University, Canada

  • Author: Ockendon, John

    University of Oxford

  • Author: Sørensen, Mads Peter

    Dynamical systems, Department of Mathematics, Technical University of Denmark

  • Author: Anderssen, Robert

    CSIRO, Mathematical and Information Sciences, Australia

  • Author: Melnik, Roderick

    Wilfrid Laurier University, Canada

  • Author: McGuinness, Mark

    Victoria University, New Zealand

  • Author: Qazi, Sanjive

    Gustavus Adolphus College, Minnesota, USA

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The HIV viruses infect cells by endocytosis and takes over parts of the cells reaction pathways in order to reproduce itself and spread the infection. One such pathway is the mammalian inflammatory signaling, which invoke NF-κB as the principal transcription factor. A treatment against HIV could be based on blocking the NF-κB pathway by a suitably designed drug. The aim of the current project is to investigate the feasibility of this idea by using mathematical modelling of the NF-κB pathway.
Original languageEnglish
Publication date2008
StatePublished

Conference

ConferenceFields-MITACS Industrial Problem-Solving Workshop
CityUniversity of Toronto, Canada, 11-15 August, 2008.
Period01/01/08 → …

Keywords

  • HIV therapies, Nonlinear models of bio systems, Inflamatory pathway
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