Differential effects of environmental chemicals and food contaminants on adipogenesis, biomarker release and PPARγ activation

Publication: Research - peer-reviewJournal article – Annual report year: 2012

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Differential effects of environmental chemicals and food contaminants on adipogenesis, biomarker release and PPARγ activation. / Taxvig, Camilla; Sørensen, Karin Dreisig; Boberg, Julie; Nellemann, Christine Lydia; Schelde, Ane Blicher; Pedersen, Dorthe; Boergesen, Michael; Mandrup, Susanne; Vinggaard, Anne Marie.

In: Molecular and Cellular Endocrinology, Vol. 361, No. 1-2, 2012, p. 106-115.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

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Author

Taxvig, Camilla; Sørensen, Karin Dreisig; Boberg, Julie; Nellemann, Christine Lydia; Schelde, Ane Blicher; Pedersen, Dorthe; Boergesen, Michael; Mandrup, Susanne; Vinggaard, Anne Marie / Differential effects of environmental chemicals and food contaminants on adipogenesis, biomarker release and PPARγ activation.

In: Molecular and Cellular Endocrinology, Vol. 361, No. 1-2, 2012, p. 106-115.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Bibtex

@article{028ef44d861e4775a3ef46a4bda585d5,
title = "Differential effects of environmental chemicals and food contaminants on adipogenesis, biomarker release and PPARγ activation",
keywords = "Adipogenesis, Endocrine disrupting chemicals, Leptin, Adiponectin, PPAR, 3T3-L1 cells",
publisher = "Elsevier Ireland Ltd",
author = "Camilla Taxvig and Sørensen, {Karin Dreisig} and Julie Boberg and Nellemann, {Christine Lydia} and Schelde, {Ane Blicher} and Dorthe Pedersen and Michael Boergesen and Susanne Mandrup and Vinggaard, {Anne Marie}",
year = "2012",
doi = "10.1016/j.mce.2012.03.021",
volume = "361",
number = "1-2",
pages = "106--115",
journal = "Molecular and Cellular Endocrinology",
issn = "0303-7207",

}

RIS

TY - JOUR

T1 - Differential effects of environmental chemicals and food contaminants on adipogenesis, biomarker release and PPARγ activation

A1 - Taxvig,Camilla

A1 - Sørensen,Karin Dreisig

A1 - Boberg,Julie

A1 - Nellemann,Christine Lydia

A1 - Schelde,Ane Blicher

A1 - Pedersen,Dorthe

A1 - Boergesen,Michael

A1 - Mandrup,Susanne

A1 - Vinggaard,Anne Marie

AU - Taxvig,Camilla

AU - Sørensen,Karin Dreisig

AU - Boberg,Julie

AU - Nellemann,Christine Lydia

AU - Schelde,Ane Blicher

AU - Pedersen,Dorthe

AU - Boergesen,Michael

AU - Mandrup,Susanne

AU - Vinggaard,Anne Marie

PB - Elsevier Ireland Ltd

PY - 2012

Y1 - 2012

N2 - Eleven environmental relevant chemicals were investigated for their ability to affect adipogenesis in vitro, biomarker release from adipocytes and PPARα and γ activation. We found that butylparaben stimulated adipogenesis in 3T3-L1 adipocytes and increased release of leptin, adiponectin and resistin from the cells. Butylparaben activated PPARγ as well, which may be a mediator of the adipogenic effect. Polychlorinated biphenyl (PCB)153 also stimulate adipogenesis and biomarker release, but did not affect PPARs. The data indicates that PPARγ activating chemicals often stimulate adipocyte differentiation although PPARγ activation is neither a requirement nor a guarantee for stimulation. Four out of the eleven chemicals (bisphenol A, mono-ethylhexyl phthalate, butylparaben, PCB 153) caused increased adipogenesis. The release of adipocyte-secreted hormones was sometimes but not always correlated with the effect on adipocyte differentiation. Eight chemicals were able to cause increased leptin release. These findings strengthen the hypothesis that chemicals can interfere with pathways related to obesity development.

AB - Eleven environmental relevant chemicals were investigated for their ability to affect adipogenesis in vitro, biomarker release from adipocytes and PPARα and γ activation. We found that butylparaben stimulated adipogenesis in 3T3-L1 adipocytes and increased release of leptin, adiponectin and resistin from the cells. Butylparaben activated PPARγ as well, which may be a mediator of the adipogenic effect. Polychlorinated biphenyl (PCB)153 also stimulate adipogenesis and biomarker release, but did not affect PPARs. The data indicates that PPARγ activating chemicals often stimulate adipocyte differentiation although PPARγ activation is neither a requirement nor a guarantee for stimulation. Four out of the eleven chemicals (bisphenol A, mono-ethylhexyl phthalate, butylparaben, PCB 153) caused increased adipogenesis. The release of adipocyte-secreted hormones was sometimes but not always correlated with the effect on adipocyte differentiation. Eight chemicals were able to cause increased leptin release. These findings strengthen the hypothesis that chemicals can interfere with pathways related to obesity development.

KW - Adipogenesis

KW - Endocrine disrupting chemicals

KW - Leptin

KW - Adiponectin

KW - PPAR

KW - 3T3-L1 cells

U2 - 10.1016/j.mce.2012.03.021

DO - 10.1016/j.mce.2012.03.021

JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

SN - 0303-7207

IS - 1-2

VL - 361

SP - 106

EP - 115

ER -