Different kinetic in incorporation and depletion of n-3 fatty acids in erythrocytes and leukocytes of mice

Publication: Research - peer-reviewJournal article – Annual report year: 2006

NullPointerException

View graph of relations

n-3 PUFA are well known for their anti-inflammatory effects. However, there has been only limited study on the kinetics of incorporation and depletion of n-3 PUFA in immune cells. In the present study we investigated the incorporation and depletion of n-3 PUFA in erythrocytes and leukocytes in mice during a 6-wk feeding period. Over the first 3-wk period (the incorporation period) the mice were fed a special diet with a high n-3/n-6 PUFA ratio. In the following 3-wk period (the depletion period) the mice were fed a standard chow diet. A linear increase of the concentration of EPA and DHA in erythrocyte membranes was observed during the incorporation period, whereas a stagnation was observed after the second week for leukocytes. The level of EPA did not fall to the background level after the depletion period, and the level of DHA was kept almost constant during the depletion period in the erythrocyte membranes. In leukocytes the concentration of both EPA and DHA decreased during the depletion period, but did not reach the background level after the 3-wk depletion. In conclusion, the kinetics of EPA and DHA in the different cells are different. The rate of incorporation is faster than that of depletion for n-3 PUFA. More n-3 PUFA can be incorporated into leukocytes in comparison with erythrocytes. The ratio of n-3/n-6 PUFA is more important than the amount of n-3 FA in changing the FA compositions of membrane lipids.
Original languageEnglish
JournalLipids
Publication date2006
Volume41
Journal number8
Pages749-752
ISSN0024-4201
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 3
Download as:
Download as PDF
Select render style:
APAAuthorCBEHarvardMLAStandardVancouverShortLong
PDF
Download as HTML
Select render style:
APAAuthorCBEHarvardMLAStandardVancouverShortLong
HTML
Download as Word
Select render style:
APAAuthorCBEHarvardMLAStandardVancouverShortLong
Word

ID: 5609784