Development of a plastic membrane containing micro-hole(s) for a potential bio-sensing application

Publication: Research - peer-reviewConference article – Annual report year: 2018

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In this work, a poly (methyl methacrylate) membrane containing micro-holes (MHs) as a prototype of a simple sensing platform of a lab-on-a-chip device has been developed for a potential analysis of clinical fluidic samples. A four probe electrochemical impedance spectroscopy (EIS) setup, with two electrodes placed on each side of the membrane, was adopted for monitoring the MH impedance (Fig. 1a). The setup was used to investigate, if EIS is suitable to sense the trapping of an analyte inside the MHs. Latex micro-beads with a diameter of 10 mu m were used to test clogging of the MHs. Additionally, finite element model simulations were performed using Comsol Multiphysics software to theoretically evaluate the sensitivity field of the EIS measurement along the MHs. (C) 2017 The Authors. Published by Elsevier Ltd.
Original languageEnglish
JournalProcedia Technology
Volume27
Pages (from-to)252-253
ISSN2212-0173
DOIs
StatePublished - 2017
EventBiosensors 2016 - Gothenburg, Sweden

Conference

ConferenceBiosensors 2016
Number26
LocationSwedish Exhibition and Congress Centre
CountrySweden
CityGothenburg
Period25/05/201627/05/2016
Internet address
CitationsWeb of Science® Times Cited: 0

    Keywords

  • Poly(methylmethacrylate), Lab-on-a-chip, Electrochemical impedance spectroscopy, Finite element model simulations
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