Detection and classification of parasite eggs for use in helminthic therapy

Publication: Research - peer-reviewArticle in proceedings – Annual report year: 2012

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Eggs from the small, intestinal pig whipworm Trichuris suis constitute the active pharmaceutical ingredient in a novel type of medicine for chronic autoimmune diseases like Crohn's disease. The pharmaceutical potency of such an egg suspension can be assessed by microscopic inspection, as only eggs containing a viable, infective larva provoke the wanted immune reaction. Thus, a precise and objective estimate of the concentration of infective eggs is crucial for dosing the new medicine. In this paper, a vision-based method for detecting and classifying T. suis parasite eggs is described. The detection is based on matched filters and the classification is done using linear and quadratic discriminant analysis on a set of biologically inspired features, including the autocorrelation-based longitudinal anisotropy and the mean scattering intensity under dark field illumination. Despite the presence of impurities and overlapping eggs, the proposed method achieves cross-validated classification rates around 93%.
Original languageEnglish
Title of host publication2012 9th IEEE International Symposium on Biomedical Imaging (ISBI)
PublisherIEEE
Publication date2012
Pages1627-1630
ISBN (print)978-1-4577-1857-1
DOIs
StatePublished

Conference

ConferenceIEEE 9th International Symposium on Biomedical Imaging (ISBI 2012)
CountrySpain
CityBarcelona
Period02/05/1205/05/12
Internet addresshttp://www.biomedicalimaging.org/2012/
CitationsWeb of Science® Times Cited: No match on DOI
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