Design of an Injectable in Situ Gelation Biomaterials for Vitreous Substitute

Publication: Research - peer-reviewJournal article – Annual report year: 2012

  • Author: Annaka, Masahiko

    Kyushu University, Japan

  • Author: Mortensen, Kell

    University of Copenhagen, Denmark

  • Author: Vigild, Martin E.

    Department of Chemical and Biochemical Engineering, Technical University of Denmark, Dansk Polymercenter DTU Bygning 423, 2800, Kgs. Lyngby, Denmark

  • Author: Matsuura, Toyoaki

    Department of Ophthalmology, Nara Medical University, Japan

  • Author: Tsuji, Souichiro

    Kyushu University, Japan

  • Author: Ueda, Tetsuo

    Department of Ophthalmology, Nara Medical University, Japan

  • Author: Tsujinaka, Hiroki

    Department of Ophthalmology, Nara Medical University, Japan

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To adapt the physical properties of living materials to their biological function, nature developed various types of polymers with outstanding physical behavior. One example is the vitreous body, which is important intraocular elements not only because of its optical and mechanical performances, but also due to its important role in the pathogenesis and treatment of conditions affecting adjacent tissues and eventually the whole eye. Here, we report a novel biocompatible material for injectable vitreous substitute, composed of thermosensitive amphiphilic polymer, which is capable of forming a transparent gel in the vitreous cavity. It is nontoxic, provides adequate support for the retina, and allows light to reach the sensory elements at the back of the eye. The amphiphilic polymer exhibits mechanical stability by assembling to form highly interconnected hydrophobic domains, which leads to the constitution of a network structure.
Original languageEnglish
JournalBiomacromolecules
Publication date2011
Volume12
Issue11
Pages4011-4021
ISSN1525-7797
DOIs
StatePublished

Bibliographical note

© 2011 American Chemical Society

CitationsWeb of Science® Times Cited: 5
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