Design and operation of a filter reactor for continuous production of a selected pharmaceutical intermediate
Publication: Research - peer-review › Journal article – Annual report year: 2012
A novel filter reactor system for continuous production of selected pharmaceutical intermediates is presented and experimentally verified. The filter reactor system consists of a mixed flow reactor equipped with a bottom filter, to retain solid reactant particles, followed by a conventional plug flow reactor, where residual reactant is converted by titration. A chemical case study, production of the pharmaceutical intermediate allylcarbinol by a reaction between allylmagnesium chloride and 2-chloro-thioxanthone, in the presence of a side reaction is considered. The synthesis is conducted in tetrahydrofuran solvent. The use of the filter reactor design was explored by examining the transferability of a synthesis step in a present full-scale semi-batch pharmaceutical production into continuous processing. The main advantages of the new continuous minireactor system, compared to the conventional semi-batch operation, are reduced impurity formation and the use of much lower reactor volumes (factor of 1000 based on the laboratory reactor) and less solvent consumption (from 5.8 to 2.3L/kg reactant). Added challenges include handling of continuous solid powder feeding, stable pumping of reactive slurries, and a possibility of continuous control.
Original language | English |
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Journal | Chemical Engineering Science |
Volume | 71 |
Pages (from-to) | 111-117 |
ISSN | 0009-2509 |
DOIs | |
State | Published - 2012 |
Citations | Web of Science® Times Cited: 11 |
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- Continuous design, Chemical reactors, Batch, Pharmaceuticals, Grignard, Optimization
Keywords
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ID: 6576637