Cyclooxygenase-2 (COX-2) Polymorphisms and Risk of Inflammatory Bowel Disease in a Scottish and Danish Case–Control Study

Publication: Research - peer-reviewJournal article – Annual report year: 2011

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Cyclooxygenase-2 (COX-2) Polymorphisms and Risk of Inflammatory Bowel Disease in a Scottish and Danish Case–Control Study. / Andersen, Vibeke; Nimmo, Elaine; Krarup, Henrik B.; Drummond, Hazel; Christensen, Jane; Ho, Gwo-tzer; Østergaard, Mette; Ernst, Anja; Lees, Charlie; Jacobsen, Bent A.; Satsangi, Jack; Vogel, Ulla Birgitte.

In: Inflammatory Bowel Diseases, Vol. 17, No. 4, 2011, p. 937-946.

Publication: Research - peer-reviewJournal article – Annual report year: 2011

Harvard

Andersen, V, Nimmo, E, Krarup, HB, Drummond, H, Christensen, J, Ho, G, Østergaard, M, Ernst, A, Lees, C, Jacobsen, BA, Satsangi, J & Vogel, UB 2011, 'Cyclooxygenase-2 (COX-2) Polymorphisms and Risk of Inflammatory Bowel Disease in a Scottish and Danish Case–Control Study' Inflammatory Bowel Diseases, vol 17, no. 4, pp. 937-946., 10.1002/ibd.21440

APA

Andersen, V., Nimmo, E., Krarup, H. B., Drummond, H., Christensen, J., Ho, G., Østergaard, M., Ernst, A., Lees, C., Jacobsen, B. A., Satsangi, J., & Vogel, U. B. (2011). Cyclooxygenase-2 (COX-2) Polymorphisms and Risk of Inflammatory Bowel Disease in a Scottish and Danish Case–Control Study. Inflammatory Bowel Diseases, 17(4), 937-946. 10.1002/ibd.21440

CBE

Andersen V, Nimmo E, Krarup HB, Drummond H, Christensen J, Ho G, Østergaard M, Ernst A, Lees C, Jacobsen BA, Satsangi J, Vogel UB. 2011. Cyclooxygenase-2 (COX-2) Polymorphisms and Risk of Inflammatory Bowel Disease in a Scottish and Danish Case–Control Study. Inflammatory Bowel Diseases. 17(4):937-946. Available from: 10.1002/ibd.21440

MLA

Vancouver

Author

Andersen, Vibeke; Nimmo, Elaine; Krarup, Henrik B.; Drummond, Hazel; Christensen, Jane; Ho, Gwo-tzer; Østergaard, Mette; Ernst, Anja; Lees, Charlie; Jacobsen, Bent A.; Satsangi, Jack; Vogel, Ulla Birgitte / Cyclooxygenase-2 (COX-2) Polymorphisms and Risk of Inflammatory Bowel Disease in a Scottish and Danish Case–Control Study.

In: Inflammatory Bowel Diseases, Vol. 17, No. 4, 2011, p. 937-946.

Publication: Research - peer-reviewJournal article – Annual report year: 2011

Bibtex

@article{d254f16a154946c7bec81f9c3fd642ee,
title = "Cyclooxygenase-2 (COX-2) Polymorphisms and Risk of Inflammatory Bowel Disease in a Scottish and Danish Case–Control Study",
publisher = "John/Wiley & Sons, Inc.",
author = "Vibeke Andersen and Elaine Nimmo and Krarup, {Henrik B.} and Hazel Drummond and Jane Christensen and Gwo-tzer Ho and Mette Østergaard and Anja Ernst and Charlie Lees and Jacobsen, {Bent A.} and Jack Satsangi and Vogel, {Ulla Birgitte}",
note = "Supported by the Lundbeck Foundation, the Danish Research Council, the Western Danish Research Forum for Health Science, the County of Viborg, the Danish Colitis-Crohn Association, the Harboe Foundation, the Familien Erichsen Mindefond, John M Klein og hustrus mindelegat, and Fonden til Lægevidenskabens fremme.",
year = "2011",
doi = "10.1002/ibd.21440",
volume = "17",
number = "4",
pages = "937--946",
journal = "Inflammatory Bowel Diseases",
issn = "1078-0998",

}

RIS

TY - JOUR

T1 - Cyclooxygenase-2 (COX-2) Polymorphisms and Risk of Inflammatory Bowel Disease in a Scottish and Danish Case–Control Study

A1 - Andersen,Vibeke

A1 - Nimmo,Elaine

A1 - Krarup,Henrik B.

A1 - Drummond,Hazel

A1 - Christensen,Jane

A1 - Ho,Gwo-tzer

A1 - Østergaard,Mette

A1 - Ernst,Anja

A1 - Lees,Charlie

A1 - Jacobsen,Bent A.

A1 - Satsangi,Jack

A1 - Vogel,Ulla Birgitte

AU - Andersen,Vibeke

AU - Nimmo,Elaine

AU - Krarup,Henrik B.

AU - Drummond,Hazel

AU - Christensen,Jane

AU - Ho,Gwo-tzer

AU - Østergaard,Mette

AU - Ernst,Anja

AU - Lees,Charlie

AU - Jacobsen,Bent A.

AU - Satsangi,Jack

AU - Vogel,Ulla Birgitte

PB - John/Wiley & Sons, Inc.

PY - 2011

Y1 - 2011

N2 - Background: Inflammatory bowel diseases (IBDs) are a result of interactions between luminal pathogens and the intestinal immune response. Cyclooxygenase-2 (COX-2) plays a key role in the regulation of the inflammatory response upon stimulation by luminal pathogens via Toll-like receptors. Methods: Genotypes of the COX-2/PTGS2/PGHS2 A-1195G (rs689466), G-765C (rs20417), and T8473C (rs5275) polymorphisms were assessed in a Scottish and Danish case–control study including 732 Crohn's disease (CD) cases, 973 ulcerative colitis (UC) cases, and 1157 healthy controls using logistic regression. Results: Carriers of the COX-2 A-1195G variant allele had increased risk of UC (odds ratio [OR], 95% confidence interval [CI] = 1.25 [1.02–1.54], P = 0.03) and of both UC and IBD among never smokers (OR [95% CI] = 1.47 [1.11–1.96], P = 0.01 and OR [95% CI] = 1.37 [1.06–1.77], P = 0.02, respectively). Furthermore, this variant genotype was associated with increased risk of diagnosis of UC before age 40 years and with extensive UC (OR [95% CI] = 1.34 [1.11–1.62], P = 0.002 and OR [95% CI] = 1.32 [1.03–1.69], P = 0.03, respectively). Conclusions: COX-2 A-1195G polymorphism was associated with the risk of UC, especially among never-smokers, suggesting that low activity of COX-2 may predispose to UC. Our results suggest that inclusion of smoking status may be essential for the evaluation of the role of genetic predisposition to IBD.

AB - Background: Inflammatory bowel diseases (IBDs) are a result of interactions between luminal pathogens and the intestinal immune response. Cyclooxygenase-2 (COX-2) plays a key role in the regulation of the inflammatory response upon stimulation by luminal pathogens via Toll-like receptors. Methods: Genotypes of the COX-2/PTGS2/PGHS2 A-1195G (rs689466), G-765C (rs20417), and T8473C (rs5275) polymorphisms were assessed in a Scottish and Danish case–control study including 732 Crohn's disease (CD) cases, 973 ulcerative colitis (UC) cases, and 1157 healthy controls using logistic regression. Results: Carriers of the COX-2 A-1195G variant allele had increased risk of UC (odds ratio [OR], 95% confidence interval [CI] = 1.25 [1.02–1.54], P = 0.03) and of both UC and IBD among never smokers (OR [95% CI] = 1.47 [1.11–1.96], P = 0.01 and OR [95% CI] = 1.37 [1.06–1.77], P = 0.02, respectively). Furthermore, this variant genotype was associated with increased risk of diagnosis of UC before age 40 years and with extensive UC (OR [95% CI] = 1.34 [1.11–1.62], P = 0.002 and OR [95% CI] = 1.32 [1.03–1.69], P = 0.03, respectively). Conclusions: COX-2 A-1195G polymorphism was associated with the risk of UC, especially among never-smokers, suggesting that low activity of COX-2 may predispose to UC. Our results suggest that inclusion of smoking status may be essential for the evaluation of the role of genetic predisposition to IBD.

KW - Single nucleotide polymorphisms

KW - Crohn's disease

KW - Ulcerative colitis

KW - Smoking status

U2 - 10.1002/ibd.21440

DO - 10.1002/ibd.21440

JO - Inflammatory Bowel Diseases

JF - Inflammatory Bowel Diseases

SN - 1078-0998

IS - 4

VL - 17

SP - 937

EP - 946

ER -