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Crosstalk between innate and adaptive immune responses to infectious bronchitis virus after vaccination and challenge of chickens varying in serum mannose-binding lectin concentrations. / Juul-Madsen, Helle R.; Norup, Liselotte R.; Jørgensen, Poul Henrik; Handberg, Kurt; Wattrang, Eva; Dalgaard, Tina S.

In: Vaccine, Vol. 29, No. 51, 2011, p. 9499-9507.

Publication: Research - peer-reviewJournal article – Annual report year: 2011

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Juul-Madsen, Helle R.; Norup, Liselotte R.; Jørgensen, Poul Henrik; Handberg, Kurt; Wattrang, Eva; Dalgaard, Tina S. / Crosstalk between innate and adaptive immune responses to infectious bronchitis virus after vaccination and challenge of chickens varying in serum mannose-binding lectin concentrations.

In: Vaccine, Vol. 29, No. 51, 2011, p. 9499-9507.

Publication: Research - peer-reviewJournal article – Annual report year: 2011

Bibtex

@article{248b4c222cfa45b18375b60ffedf3917,
title = "Crosstalk between innate and adaptive immune responses to infectious bronchitis virus after vaccination and challenge of chickens varying in serum mannose-binding lectin concentrations",
keywords = "Vaccine response, Chicken, Infectious bronchitis, Mannose-binding lectin (MBL), Challenge response",
publisher = "Elsevier Ltd.",
author = "Juul-Madsen, {Helle R.} and Norup, {Liselotte R.} and Jørgensen, {Poul Henrik} and Kurt Handberg and Eva Wattrang and Dalgaard, {Tina S.}",
year = "2011",
doi = "10.1016/j.vaccine.2011.10.016",
volume = "29",
number = "51",
pages = "9499--9507",
journal = "Vaccine",
issn = "0264-410X",

}

RIS

TY - JOUR

T1 - Crosstalk between innate and adaptive immune responses to infectious bronchitis virus after vaccination and challenge of chickens varying in serum mannose-binding lectin concentrations

A1 - Juul-Madsen,Helle R.

A1 - Norup,Liselotte R.

A1 - Jørgensen,Poul Henrik

A1 - Handberg,Kurt

A1 - Wattrang,Eva

A1 - Dalgaard,Tina S.

AU - Juul-Madsen,Helle R.

AU - Norup,Liselotte R.

AU - Jørgensen,Poul Henrik

AU - Handberg,Kurt

AU - Wattrang,Eva

AU - Dalgaard,Tina S.

PB - Elsevier Ltd.

PY - 2011

Y1 - 2011

N2 - Mannose-binding lectin (MBL), a C-type collectin with structural similarities to C1q, is an innate pattern-recognition molecule that is sequestered to sites of inflammation and infections. MBL selectively binds distinct chemical patterns, including carbohydrates expressed on all kinds of pathogens. The present study shows that serum MBL levels influence the ability of chickens to clear the respiratory tract of virus genomes after an infectious bronchitis virus (IBV) infection. The primary IBV infection induced changes in circulating T-cell populations and in the specific antibody responses. Serum MBL levels also influenced IBV vaccine-induced changes in circulating T-cell populations. Moreover, addition of mannose to an IBV vaccine altered both vaccine-induced changes in circulating T-cell populations and IBV specific vaccine and infection-induced antibody responses in chickens with high serum MBL levels. These data demonstrate that MBL is involved in the regulation of the adaptive immune response to IBV.

AB - Mannose-binding lectin (MBL), a C-type collectin with structural similarities to C1q, is an innate pattern-recognition molecule that is sequestered to sites of inflammation and infections. MBL selectively binds distinct chemical patterns, including carbohydrates expressed on all kinds of pathogens. The present study shows that serum MBL levels influence the ability of chickens to clear the respiratory tract of virus genomes after an infectious bronchitis virus (IBV) infection. The primary IBV infection induced changes in circulating T-cell populations and in the specific antibody responses. Serum MBL levels also influenced IBV vaccine-induced changes in circulating T-cell populations. Moreover, addition of mannose to an IBV vaccine altered both vaccine-induced changes in circulating T-cell populations and IBV specific vaccine and infection-induced antibody responses in chickens with high serum MBL levels. These data demonstrate that MBL is involved in the regulation of the adaptive immune response to IBV.

KW - Vaccine response

KW - Chicken

KW - Infectious bronchitis

KW - Mannose-binding lectin (MBL)

KW - Challenge response

U2 - 10.1016/j.vaccine.2011.10.016

DO - 10.1016/j.vaccine.2011.10.016

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 51

VL - 29

SP - 9499

EP - 9507

ER -