TY - JOUR

T1 - Crosstalk between innate and adaptive immune responses to infectious bronchitis virus after vaccination and challenge of chickens varying in serum mannose-binding lectin concentrations

A1 - Juul-Madsen,Helle R.

A1 - Norup,Liselotte R.

A1 - Jørgensen,Poul Henrik

A1 - Handberg,Kurt

A1 - Wattrang,Eva

A1 - Dalgaard,Tina S.

AU - Juul-Madsen,Helle R.

AU - Norup,Liselotte R.

AU - Jørgensen,Poul Henrik

AU - Handberg,Kurt

AU - Wattrang,Eva

AU - Dalgaard,Tina S.

PB - Elsevier Ltd.

PY - 2011

Y1 - 2011

N2 - Mannose-binding lectin (MBL), a C-type collectin with structural similarities to C1q, is an innate pattern-recognition molecule that is sequestered to sites of inflammation and infections. MBL selectively binds distinct chemical patterns, including carbohydrates expressed on all kinds of pathogens. The present study shows that serum MBL levels influence the ability of chickens to clear the respiratory tract of virus genomes after an infectious bronchitis virus (IBV) infection. The primary IBV infection induced changes in circulating T-cell populations and in the specific antibody responses. Serum MBL levels also influenced IBV vaccine-induced changes in circulating T-cell populations. Moreover, addition of mannose to an IBV vaccine altered both vaccine-induced changes in circulating T-cell populations and IBV specific vaccine and infection-induced antibody responses in chickens with high serum MBL levels. These data demonstrate that MBL is involved in the regulation of the adaptive immune response to IBV.

AB - Mannose-binding lectin (MBL), a C-type collectin with structural similarities to C1q, is an innate pattern-recognition molecule that is sequestered to sites of inflammation and infections. MBL selectively binds distinct chemical patterns, including carbohydrates expressed on all kinds of pathogens. The present study shows that serum MBL levels influence the ability of chickens to clear the respiratory tract of virus genomes after an infectious bronchitis virus (IBV) infection. The primary IBV infection induced changes in circulating T-cell populations and in the specific antibody responses. Serum MBL levels also influenced IBV vaccine-induced changes in circulating T-cell populations. Moreover, addition of mannose to an IBV vaccine altered both vaccine-induced changes in circulating T-cell populations and IBV specific vaccine and infection-induced antibody responses in chickens with high serum MBL levels. These data demonstrate that MBL is involved in the regulation of the adaptive immune response to IBV.

KW - Vaccine response

KW - Chicken

KW - Infectious bronchitis

KW - Mannose-binding lectin (MBL)

KW - Challenge response

U2 - 10.1016/j.vaccine.2011.10.016

DO - 10.1016/j.vaccine.2011.10.016

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 51

VL - 29

SP - 9499

EP - 9507

ER -