Control of Process Operations and Monitoring of Product Qualities through Generic Model-based Framework in Crystallization Processes
Publication: Research › Ph.D. thesis – Annual report year: 2012
also be investigated. The application of the systematic model-based framework is divided into three sections: a) the application of the generic multi-dimensional modelling framework are highlighted: i) the capability to develop and further extend a batch cooling crystallization model is illustrated through a paracetamol case study, supplemented by a sucrose crystallization example to demonstrate how the framework supports smooth switching between chemical systems with a minimum modelling effort; ii) a potassium dihydrogen phosphate (KDP) case study is used to demonstrate how the model complexity can be increased, that is, by switching from a one-dimensional to a twodimensional description; b) the systematic framework is used in a case study to design a monitoring and control (PAT) system for a potassium dichromate and KDP crystallization processes to achieve the desired target CSD respectively; and c) Based on the PAT system design in b), the application of uncertainty and sensitivity analysis is
then highlighted for the potassium dichromate and KDP crystallization process both in open-loop and closed-loop operation. In the case study, the impact of input uncertainties related to parameters of the nucleation and the crystal growth model on the predicted system performance has been investigated for a one- and two-dimensional CSD and it
shown the PAT system design is reliable and robust under considered uncertainties.
|Place of publication||Kgs.Lyngby|
|Publisher||Technical University of Denmark, Department of Chemical Engineering|
|Number of pages||238|
Note re. dissertation
This work has been financed by the Ministry of Higher Education (MOHE) of Malaysia and Universiti Malaysia Pahang (UMP).
Noor Asma Fazli Bin Abdul Samad, 2012, “Control of Process Operations and Monitoring of Product Qualities through Generic Model-based Framework in Crystallization Processes”, Ph.D. thesis