Context matters — the complex interplay between resistome genotypes and resistance phenotypes
Publication: Research - peer-review › Journal article – Annual report year: 2012
Standard
Context matters — the complex interplay between resistome genotypes and resistance phenotypes. / Dantas, Gautam; Sommer, Morten.
In: Current Opinion in Microbiology, Vol. 15, No. 5, 2012, p. 577-582.Publication: Research - peer-review › Journal article – Annual report year: 2012
Harvard
APA
CBE
MLA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Context matters — the complex interplay between resistome genotypes and resistance phenotypes
A1 - Dantas,Gautam
A1 - Sommer,Morten
AU - Dantas,Gautam
AU - Sommer,Morten
PB - Elsevier Ltd. Current Opinion Journals
PY - 2012
Y1 - 2012
N2 - Application of metagenomic functional selections to study antibiotic resistance genes is revealing a highly diverse and complex network of genetic exchange between bacterial pathogens and environmental reservoirs, which likely contributes significantly to increasing resistance levels in pathogens. In some cases, clinically relevant resistance genes have been acquired from organisms where their native function is not antibiotic resistance, and which may not even confer a resistance phenotype in their native context. In this review, we attempt to distinguish the resistance phenotype from the resistome genotype, and we highlight examples of genes and their hosts where this distinction becomes important in order to understand the relevance of environmental niches that contribute most to clinical problems associated with antibiotic resistance.
AB - Application of metagenomic functional selections to study antibiotic resistance genes is revealing a highly diverse and complex network of genetic exchange between bacterial pathogens and environmental reservoirs, which likely contributes significantly to increasing resistance levels in pathogens. In some cases, clinically relevant resistance genes have been acquired from organisms where their native function is not antibiotic resistance, and which may not even confer a resistance phenotype in their native context. In this review, we attempt to distinguish the resistance phenotype from the resistome genotype, and we highlight examples of genes and their hosts where this distinction becomes important in order to understand the relevance of environmental niches that contribute most to clinical problems associated with antibiotic resistance.
U2 - 10.1016/j.mib.2012.07.004
DO - 10.1016/j.mib.2012.07.004
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
SN - 1369-5274
IS - 5
VL - 15
SP - 577
EP - 582
ER -