Context matters — the complex interplay between resistome genotypes and resistance phenotypes

Publication: Research - peer-reviewJournal article – Annual report year: 2012

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Context matters — the complex interplay between resistome genotypes and resistance phenotypes. / Dantas, Gautam; Sommer, Morten.

In: Current Opinion in Microbiology, Vol. 15, No. 5, 2012, p. 577-582.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

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Author

Dantas, Gautam; Sommer, Morten / Context matters — the complex interplay between resistome genotypes and resistance phenotypes.

In: Current Opinion in Microbiology, Vol. 15, No. 5, 2012, p. 577-582.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Bibtex

@article{105504909d46447c9f03bb6592c9efb8,
title = "Context matters — the complex interplay between resistome genotypes and resistance phenotypes",
publisher = "Elsevier Ltd. Current Opinion Journals",
author = "Gautam Dantas and Morten Sommer",
year = "2012",
doi = "10.1016/j.mib.2012.07.004",
volume = "15",
number = "5",
pages = "577--582",
journal = "Current Opinion in Microbiology",
issn = "1369-5274",

}

RIS

TY - JOUR

T1 - Context matters — the complex interplay between resistome genotypes and resistance phenotypes

A1 - Dantas,Gautam

A1 - Sommer,Morten

AU - Dantas,Gautam

AU - Sommer,Morten

PB - Elsevier Ltd. Current Opinion Journals

PY - 2012

Y1 - 2012

N2 - Application of metagenomic functional selections to study antibiotic resistance genes is revealing a highly diverse and complex network of genetic exchange between bacterial pathogens and environmental reservoirs, which likely contributes significantly to increasing resistance levels in pathogens. In some cases, clinically relevant resistance genes have been acquired from organisms where their native function is not antibiotic resistance, and which may not even confer a resistance phenotype in their native context. In this review, we attempt to distinguish the resistance phenotype from the resistome genotype, and we highlight examples of genes and their hosts where this distinction becomes important in order to understand the relevance of environmental niches that contribute most to clinical problems associated with antibiotic resistance.

AB - Application of metagenomic functional selections to study antibiotic resistance genes is revealing a highly diverse and complex network of genetic exchange between bacterial pathogens and environmental reservoirs, which likely contributes significantly to increasing resistance levels in pathogens. In some cases, clinically relevant resistance genes have been acquired from organisms where their native function is not antibiotic resistance, and which may not even confer a resistance phenotype in their native context. In this review, we attempt to distinguish the resistance phenotype from the resistome genotype, and we highlight examples of genes and their hosts where this distinction becomes important in order to understand the relevance of environmental niches that contribute most to clinical problems associated with antibiotic resistance.

U2 - 10.1016/j.mib.2012.07.004

DO - 10.1016/j.mib.2012.07.004

JO - Current Opinion in Microbiology

JF - Current Opinion in Microbiology

SN - 1369-5274

IS - 5

VL - 15

SP - 577

EP - 582

ER -