Condition-dependent transcriptome reveals high-level regulatory architecture in Bacillus subtilis.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

  • Author: Nicolas, Pierre

  • Author: Mäder, Ulrike

  • Author: Dervyn, Etienne

  • Author: Rochat, Tatiana

  • Author: Leduc, Aurélie

  • Author: Pigeonneau, Nathalie

  • Author: Bidnenko, Elena

  • Author: Marchadier, Elodie

  • Author: Hoebeke, Mark

  • Author: Aymerich, Stéphane

  • Author: Becher, Dörte

  • Author: Bisicchia, Paola

  • Author: Botella, Eric

  • Author: Delumeau, Olivier

  • Author: Doherty, Geoff

  • Author: Denham, Emma L

  • Author: Fogg, Mark J

  • Author: Fromion, Vincent

  • Author: Goelzer, Anne

  • Author: Hansen, Annette

  • Author: Härtig, Elisabeth

  • Author: Harwood, Colin R

  • Author: Homuth, Georg

  • Author: Jarmer, Hanne

    Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Kemitorvet, 2800, Kgs. Lyngby, Denmark

  • Author: Jules, Matthieu

  • Author: Klipp, Edda

  • Author: Le Chat, Ludovic

  • Author: Lecointe, François

  • Author: Lewis, Peter

  • Author: Liebermeister, Wolfram

  • Author: March, Anika

  • Author: Mars, Ruben A T

  • Author: Nannapaneni, Priyanka

  • Author: Noone, David

  • Author: Pohl, Susanne

  • Author: Rinn, Bernd

  • Author: Rügheimer, Frank

  • Author: Sappa, Praveen K

  • Author: Samson, Franck

  • Author: Schaffer, Marc

  • Author: Schwikowski, Benno

  • Author: Steil, Leif

  • Author: Stülke, Jörg

  • Author: Wiegert, Thomas

  • Author: Devine, Kevin M

  • Author: Wilkinson, Anthony J

  • Author: van Dijl, Jan Maarten

  • Author: Hecker, Michael

  • Author: Völker, Uwe

  • Author: Bessières, Philippe

  • Author: Noirot, Philippe

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Bacteria adapt to environmental stimuli by adjusting their transcriptomes in a complex manner, the full potential of which has yet to be established for any individual bacterial species. Here, we report the transcriptomes of Bacillus subtilis exposed to a wide range of environmental and nutritional conditions that the organism might encounter in nature. We comprehensively mapped transcription units (TUs) and grouped 2935 promoters into regulons controlled by various RNA polymerase sigma factors, accounting for ~66% of the observed variance in transcriptional activity. This global classification of promoters and detailed description of TUs revealed that a large proportion of the detected antisense RNAs arose from potentially spurious transcription initiation by alternative sigma factors and from imperfect control of transcription termination.
Original languageEnglish
JournalScience
Publication date2012
Volume335
Issue6072
Pages1103-1106
ISSN0036-8075
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 102
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