Concentration-Dependant Changes of PCB Patterns in Fish-Eating Mammals.: Structural Evidence for Induction of Cytochrome P450.

Publication: Research - peer-reviewJournal article – Annual report year: 1997

  • Author: Boon, J.P.

    Netherlands Institute for Sea Research. (NIOZ)

  • Author: van der Meer, J.

    Netherlands Institute for Sea Research. (NIOZ)

  • Author: Allchin, C.R.

    Ministry of Agriculture, Fisheries and Food. (MAFF)

  • Author: Law, R.J.

    Ministry of Agriculture, Fisheries and Food. (MAFF)

  • Author: Klungsoeyr, J.

    Institute of Marine Research

  • Author: Leonards, P.E.G.

    Institute of Environmental Studies (IES)

  • Author: Spliid, Henrik

    Department of Informatics and Mathematical Modeling, Technical University of Denmark, Richard Petersens Plads, 2800, Lyngby, Denmark

  • Author: Storr-Hansen, E.

    Danish Environmental Research Institute

  • Author: Mckenzie, C.

    Scottish Office of Agriculture, Environment, Fisheries and Food (SOAEFD)

  • Author: Wells, D.E.

    Scottish Office of Agriculture, Environment, Fisheries and Food (SOAEFD)

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Data sets on CB concentrations in fish-eating mammals from five laboratories were combined to test and refine a pharmacokinetic model. Clear differences in PCB patterns were observed between species, The ability to metabolize chlorobiphenyl (CB) congeners with vicinal H-atoms only in the ortho- and meta-positions and with one ortho-chlorine substituent generally increased in the order otter < cetaceans (harbor porpoise, common dolphin) < phocid seals (harbor and grey seal), but the metabolism of congeners with vicinal H-atoms in the meta- and para-positions and with two ortho-chlorines increased in the order cetaceans < seals < otter. Both categories of congeners are probably metabolized by different families of cytochrome P450 (1A and 2B) of which levels apparently differed between the cetaceans, the pinnipeds, and the otter. Within-species CB patterns differed in a concentration-dependent manner. The induction of cytochrome P450 enzymes offers the most likely explanation for this phenomenon, but starvation could have a similar effect on occasion.
Original languageEnglish
JournalArchives of Environmental Contamination and Toxicology
Publication date1997
Volume33
Issue3
Pages298-311
ISSN0090-4341
StatePublished
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