Comparison of parasite-specific immunoglobulin levels in two chicken lines during sustained infection with Ascaridia galli

Publication: Research - peer-reviewJournal article – Annual report year: 2013

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Comparison of parasite-specific immunoglobulin levels in two chicken lines during sustained infection with Ascaridia galli. / Norup, Liselotte Rothmann; Dalgaard, Tina S.; Pleidrup, Janne; Permin, Anders; Schou, Torben Wilde; Jungersen, Gregers; Fink, Dorte R.; Juul-Madsen, Helle R.

In: Veterinary Parasitology, Vol. 191, No. 1-2, 2013, p. 187-190.

Publication: Research - peer-reviewJournal article – Annual report year: 2013

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Norup, Liselotte Rothmann; Dalgaard, Tina S.; Pleidrup, Janne; Permin, Anders; Schou, Torben Wilde; Jungersen, Gregers; Fink, Dorte R.; Juul-Madsen, Helle R. / Comparison of parasite-specific immunoglobulin levels in two chicken lines during sustained infection with Ascaridia galli.

In: Veterinary Parasitology, Vol. 191, No. 1-2, 2013, p. 187-190.

Publication: Research - peer-reviewJournal article – Annual report year: 2013

Bibtex

@article{7ccf6e273ac141779b794c2675e32ea8,
title = "Comparison of parasite-specific immunoglobulin levels in two chicken lines during sustained infection with Ascaridia galli",
publisher = "Elsevier BV",
author = "Norup, {Liselotte Rothmann} and Dalgaard, {Tina S.} and Janne Pleidrup and Anders Permin and Schou, {Torben Wilde} and Gregers Jungersen and Fink, {Dorte R.} and Juul-Madsen, {Helle R.}",
year = "2013",
doi = "10.1016/j.vetpar.2012.07.031",
volume = "191",
number = "1-2",
pages = "187--190",
journal = "Veterinary Parasitology",
issn = "0304-4017",

}

RIS

TY - JOUR

T1 - Comparison of parasite-specific immunoglobulin levels in two chicken lines during sustained infection with Ascaridia galli

A1 - Norup,Liselotte Rothmann

A1 - Dalgaard,Tina S.

A1 - Pleidrup,Janne

A1 - Permin,Anders

A1 - Schou,Torben Wilde

A1 - Jungersen,Gregers

A1 - Fink,Dorte R.

A1 - Juul-Madsen,Helle R.

AU - Norup,Liselotte Rothmann

AU - Dalgaard,Tina S.

AU - Pleidrup,Janne

AU - Permin,Anders

AU - Schou,Torben Wilde

AU - Jungersen,Gregers

AU - Fink,Dorte R.

AU - Juul-Madsen,Helle R.

PB - Elsevier BV

PY - 2013

Y1 - 2013

N2 - Increasingly large numbers of poultry are held in production systems with access to outdoor areas. In these systems intestinal helminths are found with flock prevalences of up to 100%. Helminth infections influence chicken health negatively, which is why the following investigation has been performed.In the present experiment, 20 chickens of two inbred chicken lines containing the major histocompatibility complex (MHC) haplotypes, B14 and R5, were inoculated with 500 embryonated Ascaridia galli eggs. The A. galli-specific IgG titres of serum samples and the excretion of A. galli eggs in chicken faeces were measured for a period of 81 weeks.The level of excreted A. galli eggs measured as eggs per gram chicken faeces (EPG) varied greatly between chickens in each line. Significant differences were found between the two lines and with the R5 chickens reaching the highest levels. Likewise, the A. galli-specific IgG titres in serum differed significantly between the two lines, and an inverse relationship between infection level (EPG) and antibody titres was found. Although this inverse relationship suggests that humoral immunity may be involved in protection against A. galli infection, the high antibody titres did not prevent continued infection.

AB - Increasingly large numbers of poultry are held in production systems with access to outdoor areas. In these systems intestinal helminths are found with flock prevalences of up to 100%. Helminth infections influence chicken health negatively, which is why the following investigation has been performed.In the present experiment, 20 chickens of two inbred chicken lines containing the major histocompatibility complex (MHC) haplotypes, B14 and R5, were inoculated with 500 embryonated Ascaridia galli eggs. The A. galli-specific IgG titres of serum samples and the excretion of A. galli eggs in chicken faeces were measured for a period of 81 weeks.The level of excreted A. galli eggs measured as eggs per gram chicken faeces (EPG) varied greatly between chickens in each line. Significant differences were found between the two lines and with the R5 chickens reaching the highest levels. Likewise, the A. galli-specific IgG titres in serum differed significantly between the two lines, and an inverse relationship between infection level (EPG) and antibody titres was found. Although this inverse relationship suggests that humoral immunity may be involved in protection against A. galli infection, the high antibody titres did not prevent continued infection.

KW - Chicken

KW - Ascaridia galli

KW - Immune response

KW - Immunoglobulin levels

U2 - 10.1016/j.vetpar.2012.07.031

DO - 10.1016/j.vetpar.2012.07.031

JO - Veterinary Parasitology

JF - Veterinary Parasitology

SN - 0304-4017

IS - 1-2

VL - 191

SP - 187

EP - 190

ER -