Comparative chemistry of Aspergillus oryzae (RIB40) and A. flavus (NRRL 3357)

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Documents

DOI

NullPointerException

View graph of relations

Aspergillus oryzae and A. flavus are important species in industrial biotechnology and food safety and have been some of the first aspergilli to be fully genome sequenced. Bioinformatic analysis has revealed 99.5% gene homology between the two species pointing towards a large coherence in the secondary metabolite production. In this study we report on the first comparison of secondary metabolite production between the full genome sequenced strains of A. oryzae (RIB40) and A. flavus (NRRL 3357). Surprisingly, the overall chemical profiles of the two strains were mostly very different across 15 growth conditions. Contrary to previous studies we found the aflatrem precursor 13-desoxypaxilline to be a major metabolite from A. oryzae under certain growth conditions. For the first time, we additionally report A. oryzae to produce parasiticolide A and two new analogues hereof, along with four new alkaloids related to the A. flavus metabolites ditryptophenalines and miyakamides. Generally the secondary metabolite capability of A. oryzae presents several novel end products likely to result from the domestication process from A. flavus.
Original languageEnglish
JournalMetabolites
Publication date2012
Volume2
Pages39-56
ISSN2218-1989
DOIs
StatePublished
CitationsWeb of Science® Times Cited: No match on DOI

Keywords

  • Aspergillus oryzae, (RIB40), Aspergillus flavus, (NRRL 3357), parasiticolide, ditryptoleucine, oryzamide
Download as:
Download as PDF
Select render style:
APAAuthorCBEHarvardMLAStandardVancouverShortLong
PDF
Download as HTML
Select render style:
APAAuthorCBEHarvardMLAStandardVancouverShortLong
HTML
Download as Word
Select render style:
APAAuthorCBEHarvardMLAStandardVancouverShortLong
Word

Download statistics

No data available

ID: 12830830